COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02876-0017-0000-3
Chemical Name: Tetrachloroethylene
CASRN: 127-18-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 053083_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/05/1993 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 337026 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    337036 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    337041 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    337059 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    337060 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337065 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    337069 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337073 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    337078 50 2 2 0 0 1 2 0 7 0.14 0.10 10.00 6.00
    337108 50 3 6 0 1 0 0 0 10 0.20 0.06 16.00 8.00
Average         1.3 2.0 0.0 0.1 0.1 0.3 0.0 3.8 0.08 0.03 6.25 3.00
± SEM                         0.02 0.01 1.71 0.93
 
Test Chemical Tetrachloroethylene 
1000         
 337010 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337015 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    337016 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337030 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337037 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337045 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337063 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337083 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    337131 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.00 0.75 0.25
± SEM                         0.01 0.00 0.53 0.25
 
Test Chemical Tetrachloroethylene 
1500         
 337001 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337014 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337021 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337023 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    337025 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337040 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337044 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    337054 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    337074 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    337133 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.9 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.00 1.75 0.25
± SEM                         0.01 0.00 0.70 0.25
 
Test Chemical Tetrachloroethylene 
2000         
 337004 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    337007 50 3 1 0 0 0 1 0 5 0.10 0.08 8.00 6.00
    337012 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    337013 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337027 50 1 5 0 0 0 0 0 6 0.12 0.02 12.00 2.00
    337028 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    337056 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337062 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337068 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    337070 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.3 2.0 0.0 0.0 0.0 0.1 0.0 3.4 0.07 0.03 6.00 2.50
± SEM                         0.02 0.01 1.46 0.73
 
Test Chemical Tetrachloroethylene 
2500         
 337020 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    337029 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337035 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337066 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337071 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337132 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    337135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.00 1.43 0.29
± SEM                         0.01 0.00 0.57 0.29
 
Vehicle Control No Stressor 
 0         
 337003 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337005 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337018 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337039 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337043 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    337052 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337057 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337064 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337123 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    337134 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.50 0.00
± SEM                         0.01 0.00 0.50 0.00
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation