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Study Information
Study Attribute Value
CEBS Accession Number: 002-02876-0017-0000-3
Chemical Name: Tetrachloroethylene
CASRN: 127-18-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 053083_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/02/1993 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 357003 50 2 3 1 0 0 0 0 6 0.12 0.06 12.00 6.00
    357007 50 0 4 0 1 0 0 0 5 0.10 0.00 8.00 0.00
    357032 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357038 50 3 6 0 1 0 0 0 10 0.20 0.06 16.00 6.00
    357098 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357108 50 0 6 1 1 0 0 0 8 0.16 0.02 16.00 2.00
    357121 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    357131 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    357135 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    357149 50 5 4 1 0 0 0 0 10 0.20 0.12 16.00 10.00
Average         1.6 4.1 0.4 0.4 0.0 0.0 0.0 6.5 0.13 0.04 11.50 3.75
± SEM                         0.02 0.02 1.40 1.33
 
Positive Control Dimethylbenzanthracene 
200         
 357009 50 7 7 0 0 0 0 0 14 0.28 0.14 22.00 14.00
    357020 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 4.00
    357029 50 3 5 0 0 0 0 0 8 0.16 0.06 14.00 6.00
    357046 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357047 50 2 6 0 0 0 0 0 8 0.16 0.04 8.00 2.00
    357048 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357068 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    357072 50 5 3 0 1 0 0 0 9 0.18 0.10 16.00 10.00
    357084 50 5 7 0 1 0 0 0 13 0.26 0.10 18.00 8.00
    357151 50 4 6 1 1 0 0 0 12 0.24 0.10 20.00 10.00
Average         3.8 4.9 0.1 0.4 0.0 0.0 0.0 9.1 0.18 0.08 14.00 7.00
± SEM                         0.03 0.01 2.14 1.51
 
Test Chemical Tetrachloroethylene 
1500         
 357014 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357019 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357033 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357106 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    357109 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    357111 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357114 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357115 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357142 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357148 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 1.0 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.00 1.75 0.25
± SEM                         0.01 0.00 0.80 0.25
 
Test Chemical Tetrachloroethylene 
2000         
 357004 50 2 4 0 0 0 0 0 6 0.12 0.04 12.00 4.00
    357010 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    357015 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    357027 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    357053 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357058 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357064 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357101 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357103 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.5 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.01 3.50 0.75
± SEM                         0.01 0.01 1.35 0.53
 
Test Chemical Tetrachloroethylene 
2500         
 357018 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357022 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357070 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357073 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357119 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357123 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357129 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357132 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357160 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    357169 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357178 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.1 1.0 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.00 2.25 0.25
± SEM                         0.00 0.00 0.45 0.25
 
Vehicle Control No Stressor 
 0         
 357016 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    357036 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357061 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357094 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357105 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357116 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    357117 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357127 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    357130 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    357136 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.9 0.0 0.1 0.0 0.0 0.0 1.5 0.03 0.01 2.50 1.00
± SEM                         0.01 0.01 1.12 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation