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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0016-0000-2
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 056227_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/15/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 9483 50 9 9 0 0 0 0 0 18 0.36 0.18 26.00 12.00
    9486 50 8 10 0 0 0 0 1 19 0.38 0.18 26.00 16.00
    9500 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    9510 50 0 0 0 2 0 0 0 2 0.04 0.00 10.00 4.00
    9516 50 3 9 0 0 0 0 0 12 0.24 0.06 16.00 6.00
    9517 50 3 7 0 0 0 0 0 10 0.20 0.06 16.00 6.00
    9521 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    9531 50 12 14 0 0 0 0 0 26 0.52 0.24 26.00 14.00
Average         5.4 6.9 0.0 0.3 0.0 0.0 0.1 12.6 0.25 0.11 18.25 9.25
± SEM                         0.06 0.03 2.37 1.56
 
Test Chemical Allyl isothiocyanate 
12.5       
 9485 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9490 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9493 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9501 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9505 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9514 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9522 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9535 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.50 0.00
± SEM                         0.00 0.00 0.33 0.00
 
Test Chemical Allyl isothiocyanate 
25         
 9487 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9496 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9497 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9507 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9511 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9518 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9526 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9534 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.5 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 0.75
± SEM                         0.01 0.00 0.59 0.37
 
Test Chemical Allyl isothiocyanate 
50         
 9484 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9488 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9491 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9495 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9499 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9504 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9515 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9520 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.4 0.8 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.25 0.75
± SEM                         0.01 0.01 0.70 0.53
 
Vehicle Control No Stressor 
 0         
 9489 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9492 50 0 2 0 1 0 0 0 3 0.06 0.00 6.00 0.00
    9498 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9503 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9506 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    9528 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9530 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9532 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 1.1 0.0 0.1 0.0 0.0 0.0 1.4 0.03 0.00 2.50 0.25
± SEM                         0.01 0.00 0.82 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation