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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0016-0000-2
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 056227_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/29/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9727 50 46 10 0 0 0 0 0 56 1.12 0.92 34.00 20.00
    9734 50 19 14 0 2 0 0 0 35 0.70 0.38 32.00 18.00
    9743 50 17 7 0 0 0 0 0 24 0.48 0.34 22.00 12.00
    9757 50 6 3 0 0 0 0 0 9 0.18 0.12 16.00 12.00
    9766 50 22 13 0 0 0 0 0 35 0.70 0.44 36.00 22.00
    9772 50 18 5 0 0 0 0 0 23 0.46 0.36 26.00 22.00
    9777 50 21 13 0 0 0 0 1 35 0.70 0.44 34.00 20.00
    9792 50 16 18 0 0 0 0 0 34 0.68 0.32 48.00 26.00
Average         20.6 10.4 0.0 0.3 0.0 0.0 0.1 31.4 0.63 0.42 31.00 19.00
± SEM                         0.10 0.08 3.44 1.73
 
Test Chemical Allyl isothiocyanate 
12.5       
 9732 50 1 1 0 0 0 0 1 3 0.06 0.04 2.00 2.00
    9733 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9739 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9749 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9750 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9752 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9758 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9769 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.1 0.0 0.0 0.0 0.0 0.1 1.6 0.03 0.01 2.75 0.75
± SEM                         0.01 0.01 0.65 0.37
 
Test Chemical Allyl isothiocyanate 
25         
 9726 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9729 50 2 3 0 0 0 0 1 6 0.12 0.06 10.00 4.00
    9735 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9754 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9755 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9760 50 2 5 0 0 0 0 0 7 0.14 0.04 10.00 2.00
    9764 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9767 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.8 2.1 0.0 0.0 0.0 0.0 0.1 3.0 0.06 0.02 5.25 1.25
± SEM                         0.02 0.01 1.19 0.53
 
Test Chemical Allyl isothiocyanate 
50         
 9728 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    9731 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9738 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9744 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    9748 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 2.00
    9756 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9761 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9762 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.1 1.9 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.02 5.75 2.25
± SEM                         0.01 0.01 1.03 0.59
 
Vehicle Control No Stressor 
 0         
 9740 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9746 50 4 7 0 0 0 0 0 11 0.22 0.08 12.00 6.00
    9751 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9753 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9763 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9768 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9780 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9794 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 1.6 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.01 3.00 0.75
± SEM                         0.03 0.01 1.36 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation