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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0016-0000-2
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 056227_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/14/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 10715 50 18 4 0 1 0 0 1 24 0.48 0.38 22.00 16.00
    10723 50 11 16 0 0 0 0 0 27 0.54 0.22 32.00 16.00
    10727 50 13 11 0 0 0 0 0 24 0.48 0.26 30.00 8.00
    10733 50 31 5 0 0 0 0 0 36 0.72 0.62 22.00 16.00
    10742 50 45 14 0 0 0 0 1 60 1.20 0.92 44.00 32.00
    10748 50 11 6 0 1 0 0 0 18 0.36 0.22 26.00 24.00
    10749 50 10 21 0 0 0 0 0 31 0.62 0.20 40.00 20.00
    10751 50 10 11 1 0 0 0 0 22 0.44 0.22 26.00 18.00
Average         18.6 11.0 0.1 0.3 0.0 0.0 0.3 30.3 0.61 0.38 30.25 18.75
± SEM                         0.09 0.09 2.86 2.48
 
Test Chemical Allyl isothiocyanate 
25         
 10716 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10722 50 5 2 0 0 0 0 0 7 0.14 0.10 10.00 8.00
    10738 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10745 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10747 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10757 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10758 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10759 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.9 1.1 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.50 1.50
± SEM                         0.02 0.01 1.18 0.98
 
Test Chemical Allyl isothiocyanate 
37.5       
 10721 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10726 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
    10730 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10732 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10736 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10739 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    10740 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10755 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 1.1 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.02 4.00 2.25
± SEM                         0.01 0.00 1.00 0.45
 
Test Chemical Allyl isothiocyanate 
50         
 10714 50 1 2 0 0 0 0 0 3 0.06 0.02 8.00 4.00
    10717 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10724 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    10728 50 5 1 0 0 0 0 0 6 0.12 0.10 14.00 12.00
    10750 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10752 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    10756 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10761 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.5 0.9 0.0 0.0 0.0 0.0 0.1 2.5 0.05 0.03 5.00 3.50
± SEM                         0.01 0.01 1.56 1.35
 
Vehicle Control No Stressor 
 0         
 10713 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    10725 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10729 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10737 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10741 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10746 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10753 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10760 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.1 1.1 0.02 0.02 2.00 1.25
± SEM                         0.01 0.01 0.65 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation