| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01633-0015-0000-1 |
| Chemical Name: | Allyl isothiocyanate |
| CASRN: | 57-06-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 056227_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/02/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
9334 | 25 | 4.84 | ± | 0.381 |
| 9336 | 24 | 3.38 | ± | 0.295 | |||
| 9348 | 25 | 5.10 | ± | 0.410 | |||
| 9354 | 24 | 5.03 | ± | 0.499 | |||
| Average | 4.59 | ± | 0.405 | ||||
| Test Chemical | Allyl isothiocyanate |
12.5 |
9331 | 25 | 3.99 | ± | 0.452 |
| 9333 | 25 | 4.60 | ± | 0.490 | |||
| 9350 | 24 | 4.92 | ± | 0.378 | |||
| 9353 | 25 | 6.80 | ± | 0.645 | |||
| Average | 5.08 | ± | 0.605 | ||||
| Test Chemical | Allyl isothiocyanate |
25 |
9328 | 25 | 4.51 | ± | 0.430 |
| 9330 | 25 | 4.55 | ± | 0.334 | |||
| 9335 | 25 | 6.07 | ± | 0.458 | |||
| 9345 | 25 | 6.44 | ± | 0.429 | |||
| Average | 5.39 | ± | 0.504 | ||||
| Test Chemical | Allyl isothiocyanate |
50 |
9337 | 24 | 5.56 | ± | 0.484 |
| 9339 | 25 | 5.83 | ± | 0.541 | |||
| 9344 | 25 | 9.47 | ± | 0.979 | |||
| 9347 | 25 | 8.67 | ± | 0.724 | |||
| Average | 7.39 | ± | 0.990 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
9329 | 25 | 15.36 | ± | 1.498 |
| 9338 | 25 | 14.11 | ± | 1.138 | |||
| 9346 | 25 | 11.72 | ± | 0.867 | |||
| 9352 | 25 | 14.83 | ± | 0.956 | |||
| Average | 13.99 | ± | 0.802 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed