| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01633-0015-0000-1 |
| Chemical Name: | Allyl isothiocyanate |
| CASRN: | 57-06-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 056227_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/01/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
9812 | 25 | 4.89 | ± | 0.506 |
| 9814 | 25 | 4.84 | ± | 0.510 | |||
| 9820 | 25 | 3.89 | ± | 0.339 | |||
| 9833 | 25 | 4.57 | ± | 0.489 | |||
| Average | 4.56 | ± | 0.230 | ||||
| Test Chemical | Allyl isothiocyanate |
12.5 |
9813 | 25 | 4.26 | ± | 0.346 |
| 9832 | 25 | 5.52 | ± | 0.507 | |||
| 9834 | 25 | 5.67 | ± | 0.526 | |||
| 9837 | 25 | 5.72 | ± | 0.549 | |||
| Average | 5.29 | ± | 0.347 | ||||
| Test Chemical | Allyl isothiocyanate |
25 |
9815 | 25 | 5.47 | ± | 0.445 |
| 9818 | 25 | 6.01 | ± | 0.558 | |||
| 9823 | 25 | 6.04 | ± | 0.481 | |||
| 9839 | 25 | 5.00 | ± | 0.547 | |||
| Average | 5.63 | ± | 0.246 | ||||
| Test Chemical | Allyl isothiocyanate |
50 |
9824 | 25 | 5.93 | ± | 0.431 |
| 9825 | 25 | 4.75 | ± | 0.347 | |||
| 9826 | 25 | 5.84 | ± | 0.394 | |||
| 9830 | 25 | 8.17 | ± | 0.803 | |||
| Average | 6.18 | ± | 0.718 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
9819 | 25 | 11.33 | ± | 0.615 |
| 9822 | 25 | 11.94 | ± | 0.952 | |||
| 9828 | 25 | 14.55 | ± | 1.127 | |||
| 9836 | 25 | 13.30 | ± | 1.130 | |||
| Average | 12.79 | ± | 0.720 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed