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Study Information
Study Attribute Value
CEBS Accession Number: 002-01043-0017-0000-8
Chemical Name: 1,2-Dibromo-3-chloropropane
CASRN: 96-12-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 063791_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/10/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 2956 50 7 4 1 1 1 0 0 14 0.28 0.18 16.00 10.00
    2957 50 5 8 0 0 0 0 0 13 0.26 0.10 16.00 8.00
    2959 50 10 11 0 0 0 0 1 22 0.44 0.22 28.00 18.00
    2960 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    2961 50 6 3 0 0 0 0 0 9 0.18 0.12 14.00 12.00
    2962 50 5 1 0 0 1 0 0 7 0.14 0.12 12.00 10.00
    2963 50 9 5 0 0 1 0 0 15 0.30 0.20 26.00 18.00
    2964 50 11 4 1 1 0 0 0 17 0.34 0.24 20.00 16.00
Average         6.9 4.8 0.3 0.3 0.4 0.0 0.1 12.6 0.25 0.15 17.50 12.00
± SEM                         0.04 0.02 2.41 1.77
 
Test Chemical 1,2-Dibromo-3-chloropropane 
25         
 2885 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2886 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2887 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2888 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2889 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    2890 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2891 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2892 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.75
± SEM                         0.01 0.01 0.76 0.53
 
Test Chemical 1,2-Dibromo-3-chloropropane 
50         
 2895 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2896 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2898 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2901 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2902 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2903 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2904 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2905 50 3 0 0 0 0 0 1 4 0.08 0.08 8.00 8.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.1 1.3 0.03 0.02 2.50 1.75
± SEM                         0.01 0.01 0.91 0.96
 
Test Chemical 1,2-Dibromo-3-chloropropane 
100         
 2906 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2907 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    2908 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    2909 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2910 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2911 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    2912 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2913 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.4 0.0 0.1 0.0 0.0 0.1 1.6 0.03 0.02 3.25 2.25
± SEM                         0.01 0.00 0.75 0.45
 
Vehicle Control No Stressor 
 0         
 2846 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2947 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    2948 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2949 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    2950 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    2951 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2952 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2953 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.00 2.25
± SEM                         0.01 0.01 1.20 0.96
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation