| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01043-0016-0000-7 |
| Chemical Name: | 1,2-Dibromo-3-chloropropane |
| CASRN: | 96-12-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 063791_SCE |
| Study Result: | Equivocal |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/10/1985 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | IP/IJ x 1, 17 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2947 | 25 | 2.64 | ± | 0.399 |
| 2949 | 25 | 3.93 | ± | 0.300 | |||
| 2950 | 25 | 4.17 | ± | 0.431 | |||
| 2951 | 25 | 4.18 | ± | 0.593 | |||
| Average | 3.73 | ± | 0.366 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
25 |
2886 | 25 | 4.60 | ± | 0.423 |
| 2887 | 25 | 4.12 | ± | 0.600 | |||
| 2888 | 25 | 4.78 | ± | 0.455 | |||
| 2889 | 25 | 5.89 | ± | 0.509 | |||
| Average | 4.85 | ± | 0.375 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
50 |
2895 | 25 | 5.11 | ± | 0.534 |
| 2896 | 25 | 5.70 | ± | 0.624 | |||
| 2898 | 25 | 6.88 | ± | 0.682 | |||
| 2899 | 25 | 4.59 | ± | 0.357 | |||
| Average | 5.57 | ± | 0.492 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
100 |
2907 | 25 | 4.50 | ± | 0.440 |
| 2908 | 25 | 6.05 | ± | 0.505 | |||
| 2909 | 25 | 5.78 | ± | 0.431 | |||
| 2910 | 25 | 6.00 | ± | 0.551 | |||
| Average | 5.58 | ± | 0.365 | ||||
| Positive Control | Dimethylbenzanthracene |
100 |
2956 | 25 | 10.15 | ± | 0.654 |
| 2957 | 25 | 10.01 | ± | 0.604 | |||
| 2959 | 25 | 10.64 | ± | 1.021 | |||
| 2960 | 25 | 10.80 | ± | 1.100 | |||
| Average | 10.41 | ± | 0.191 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed