| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01043-0016-0000-7 |
| Chemical Name: | 1,2-Dibromo-3-chloropropane |
| CASRN: | 96-12-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 063791_SCE |
| Study Result: | Equivocal |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/20/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3035 | 25 | 3.52 | ± | 0.465 |
| 3036 | 25 | 5.44 | ± | 0.447 | |||
| 3037 | 25 | 4.85 | ± | 0.546 | |||
| 3038 | 25 | 4.40 | ± | 0.427 | |||
| Average | 4.56 | ± | 0.405 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
25 |
3010 | 25 | 8.10 | ± | 0.866 |
| 3011 | 25 | 5.81 | ± | 0.459 | |||
| 3012 | 25 | 5.21 | ± | 0.494 | |||
| 3013 | 25 | 6.14 | ± | 0.549 | |||
| Average | 6.32 | ± | 0.624 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
50 |
3015 | 25 | 4.90 | ± | 0.481 |
| 3016 | 25 | 5.16 | ± | 0.610 | |||
| 3017 | 25 | 5.05 | ± | 0.590 | |||
| 3018 | 25 | 4.69 | ± | 0.538 | |||
| Average | 4.95 | ± | 0.102 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
100 |
3020 | 25 | 6.33 | ± | 0.607 |
| 3021 | 25 | 7.17 | ± | 0.547 | |||
| 3022 | 25 | 4.76 | ± | 0.551 | |||
| 3023 | 25 | 7.82 | ± | 0.773 | |||
| Average | 6.52 | ± | 0.661 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3025 | 25 | 9.07 | ± | 0.914 |
| 3026 | 25 | 11.11 | ± | 1.034 | |||
| 3027 | 25 | 9.89 | ± | 0.992 | |||
| 3028 | 25 | 12.20 | ± | 1.241 | |||
| Average | 10.59 | ± | 0.688 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed