| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01043-0016-0000-7 |
| Chemical Name: | 1,2-Dibromo-3-chloropropane |
| CASRN: | 96-12-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 063791_SCE |
| Study Result: | Equivocal |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/30/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6048 | 25 | 5.68 | ± | 0.582 |
| 6049 | 25 | 4.68 | ± | 0.390 | |||
| 6051 | 25 | 3.44 | ± | 0.428 | |||
| 6052 | 25 | 4.80 | ± | 0.443 | |||
| Average | 4.65 | ± | 0.462 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
25 |
6033 | 25 | 4.17 | ± | 0.569 |
| 6034 | 25 | 5.68 | ± | 0.473 | |||
| 6035 | 25 | 6.38 | ± | 0.446 | |||
| 6036 | 25 | 2.65 | ± | 0.354 | |||
| Average | 4.72 | ± | 0.829 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
50 |
6038 | 25 | 3.52 | ± | 0.480 |
| 6039 | 25 | 4.31 | ± | 0.358 | |||
| 6040 | 25 | 4.19 | ± | 0.546 | |||
| 6041 | 25 | 8.09 | ± | 0.814 | |||
| Average | 5.03 | ± | 1.035 | ||||
| Test Chemical | 1,2-Dibromo-3-chloropropane |
100 |
6043 | 25 | 5.34 | ± | 0.747 |
| 6044 | 25 | 4.76 | ± | 0.440 | |||
| 6045 | 25 | 8.72 | ± | 0.662 | |||
| 6046 | 25 | 3.53 | ± | 0.455 | |||
| Average | 5.59 | ± | 1.111 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6053 | 25 | 12.08 | ± | 1.063 |
| 6054 | 25 | 9.76 | ± | 0.910 | |||
| 6055 | 25 | 10.27 | ± | 1.190 | |||
| 6056 | 25 | 12.37 | ± | 1.040 | |||
| Average | 11.12 | ± | 0.651 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed