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Study Information
Study Attribute Value
CEBS Accession Number: 002-02229-0012-0000-0
Chemical Name: HC blue 1
CASRN: 2784-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 069905_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/17/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4300 50 9 3 0 0 0 0 0 12 0.24 0.18 22.00 16.00
    4307 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
    4308 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    4309 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4311 50 5 0 0 0 0 0 0 5 0.10 0.10 6.00 6.00
    4316 50 8 2 0 0 0 0 0 10 0.20 0.16 16.00 12.00
    4326 50 7 4 0 0 0 0 1 12 0.24 0.16 24.00 16.00
    4331 50 3 0 0 0 0 0 0 3 0.06 0.06 8.00 8.00
Average         5.1 1.8 0.0 0.0 0.0 0.0 0.1 7.0 0.14 0.11 13.00 9.50
± SEM                         0.03 0.02 2.54 1.72
 
Test Chemical HC blue 1 
375         
 4314 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4317 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4318 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4319 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4320 50 5 1 0 0 0 0 0 6 0.12 0.10 8.00 6.00
    4322 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    4324 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4330 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.6 0.4 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.04 3.50 2.75
± SEM                         0.01 0.01 0.91 0.75
 
Test Chemical HC blue 1 
500         
 4301 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4305 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    4312 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    4328 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4329 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4333 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4334 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.1 1.8 0.04 0.03 3.00 2.25
± SEM                         0.01 0.01 1.07 0.70
 
Vehicle Control No Stressor 
 0         
 4295 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4297 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4298 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4315 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4321 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 0.00
    4323 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    4325 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4332 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
Average         0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.01 0.01 0.50 0.25
± SEM                         0.01 0.01 0.33 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation