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Study Information
Study Attribute Value
CEBS Accession Number: 002-02229-0012-0000-0
Chemical Name: HC blue 1
CASRN: 2784-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 069905_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/12/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7348 50 42 14 0 0 0 0 2 58 1.16 0.88 42.00 40.00
    7362 50 52 10 0 0 0 0 0 62 1.24 1.04 44.00 40.00
    7375 50 61 8 0 0 1 0 0 70 1.40 1.24 42.00 32.00
    7383 50 24 14 0 0 1 0 1 40 0.80 0.52 38.00 32.00
    7391 50 52 6 1 0 0 0 2 61 1.22 1.10 40.00 38.00
    7394 50 42 8 0 1 0 0 1 52 1.04 0.86 34.00 30.00
    7396 50 36 11 0 0 0 1 0 48 0.96 0.74 34.00 26.00
    7412 50 64 11 0 0 0 0 2 77 1.54 1.32 46.00 40.00
Average         46.6 10.3 0.1 0.1 0.3 0.1 1.0 58.5 1.17 0.96 40.00 34.75
± SEM                         0.08 0.09 1.56 1.92
 
Test Chemical HC blue 1 
125         
 7349 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7355 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7363 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7364 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7370 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    7373 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7374 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    7378 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.3 0.5 0.0 0.0 0.0 0.0 0.1 1.9 0.04 0.03 3.50 2.50
± SEM                         0.01 0.01 0.91 0.50
 
Test Chemical HC blue 1 
250         
 7354 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7356 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7360 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7366 50 3 0 0 0 0 0 1 4 0.08 0.08 6.00 6.00
    7369 50 3 1 0 0 0 0 1 5 0.10 0.08 6.00 6.00
    7377 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    7381 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7384 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.5 1.1 0.0 0.0 0.0 0.0 0.3 2.9 0.06 0.04 5.00 3.00
± SEM                         0.01 0.01 0.76 0.93
 
Test Chemical HC blue 1 
500         
 7345 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7347 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    7361 50 2 0 0 0 0 0 0 2 0.04 0.04 6.00 6.00
    7365 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 10.00
    7371 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7376 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7380 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7382 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.6 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.05 0.03 5.00 3.50
± SEM                         0.01 0.01 1.25 1.18
 
Vehicle Control No Stressor 
 0         
 7346 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7350 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7358 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7368 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7372 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    7386 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7405 50 0 0 0 0 0 0 2 2 0.04 0.04 0.00 0.00
    7420 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.6 1.5 0.03 0.02 1.75 1.00
± SEM                         0.01 0.01 0.70 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation