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Study Information
Study Attribute Value
CEBS Accession Number: 002-01728-0016-0000-7
Chemical Name: Bisphenol A
CASRN: 80-05-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 070061_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/22/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4274 50 1 2 1 0 0 0 0 4 0.08 0.04 8.00 4.00
    4275 50 7 4 0 1 0 0 0 12 0.24 0.14 18.00 14.00
    4276 50 3 1 0 3 0 0 0 7 0.14 0.06 8.00 6.00
    4277 50 7 4 0 0 0 0 0 11 0.22 0.14 16.00 12.00
    4278 50 3 4 0 0 0 0 0 7 0.14 0.06 12.00 8.00
    4279 50 8 2 0 1 1 0 1 13 0.26 0.20 20.00 16.00
    4280 50 4 1 0 0 0 0 2 7 0.14 0.12 10.00 10.00
    4281 50 2 0 0 4 0 0 0 6 0.12 0.04 8.00 2.00
Average         4.4 2.3 0.1 1.1 0.1 0.0 0.4 8.4 0.17 0.10 12.50 9.00
± SEM                         0.02 0.02 1.72 1.73
 
Test Chemical Bisphenol A 
62.5       
 4234 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    4235 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4236 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4237 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    4238 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    4239 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4240 50 2 4 0 0 0 0 0 6 0.12 0.04 12.00 4.00
    4241 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.4 1.4 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.03 5.00 2.50
± SEM                         0.01 0.01 1.13 0.50
 
Test Chemical Bisphenol A 
125         
 4224 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4225 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4226 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4227 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4228 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4229 50 1 4 0 0 0 0 1 6 0.12 0.04 6.00 4.00
    4230 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    4231 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.6 0.1 0.0 0.0 0.0 0.1 1.9 0.04 0.03 3.00 2.50
± SEM                         0.01 0.01 0.76 0.73
 
Test Chemical Bisphenol A 
250         
 4214 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4215 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4216 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    4217 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4218 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4219 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    4220 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4221 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.5 0.0 0.0 0.0 0.0 0.1 1.4 0.03 0.02 2.50 1.75
± SEM                         0.01 0.01 0.91 0.70
 
Vehicle Control No Stressor 
 0         
 4284 50 4 2 1 0 0 0 0 7 0.14 0.10 12.00 10.00
    4285 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4286 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4287 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4288 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    4289 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4290 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4291 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.4 0.1 0.0 0.0 0.0 0.1 1.8 0.04 0.03 3.25 2.75
± SEM                         0.02 0.01 1.36 1.13
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation