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Study Information
Study Attribute Value
CEBS Accession Number: 002-01728-0016-0000-7
Chemical Name: Bisphenol A
CASRN: 80-05-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 070061_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/17/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11251 50 89 11 0 0 0 0 0 100 2.00 1.78 46.00 34.00
    11252 50 49 10 1 2 0 0 0 62 1.24 1.00 50.00 34.00
    11253 50 29 18 1 0 0 0 1 49 0.98 0.62 42.00 28.00
    11254 50 38 5 0 0 0 0 1 44 0.88 0.78 34.00 28.00
    11255 50 59 15 0 0 0 0 0 74 1.48 1.18 44.00 26.00
    11256 50 76 8 1 0 0 0 0 85 1.70 1.54 30.00 20.00
    11257 50 124 4 3 0 0 0 0 131 2.62 2.54 52.00 46.00
    11259 50 32 12 0 0 0 0 0 44 0.88 0.64 20.00 10.00
Average         62.0 10.4 0.8 0.3 0.0 0.0 0.3 73.6 1.47 1.26 39.75 28.25
± SEM                         0.22 0.23 3.86 3.75
 
Test Chemical Bisphenol A 
37.5       
 11180 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11181 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11182 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11183 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    11184 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11185 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11186 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11187 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.00 1.00
± SEM                         0.01 0.00 0.65 0.38
 
Test Chemical Bisphenol A 
75         
 11190 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    11191 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11192 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11193 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 0.00
    11194 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11195 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11196 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11197 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.1 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.03 2.25 1.75
± SEM                         0.01 0.01 0.80 0.88
 
Test Chemical Bisphenol A 
150         
 11200 50 3 2 1 0 0 0 0 6 0.12 0.08 12.00 8.00
    11201 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11202 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11204 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11206 50 4 4 0 0 0 0 0 8 0.16 0.08 8.00 4.00
    11207 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11208 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11209 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.5 1.3 0.1 0.0 0.0 0.0 0.0 2.9 0.06 0.03 4.75 2.75
± SEM                         0.02 0.01 1.46 1.06
 
Vehicle Control No Stressor 
 0         
 11240 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11241 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11242 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11243 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11244 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11245 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11246 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11247 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.5 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 1.00
± SEM                         0.01 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation