| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01728-0015-0000-6 |
| Chemical Name: | Bisphenol A |
| CASRN: | 80-05-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 070061_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/15/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
4446 | 25 | 4.42 | ± | 0.559 |
| 4447 | 25 | 4.92 | ± | 0.472 | |||
| 4448 | 25 | 3.73 | ± | 0.417 | |||
| 4449 | 25 | 4.41 | ± | 0.629 | |||
| Average | 4.38 | ± | 0.244 | ||||
| Test Chemical | Bisphenol A |
62.5 |
4441 | 25 | 5.21 | ± | 0.660 |
| 4442 | 25 | 4.46 | ± | 0.426 | |||
| 4443 | 25 | 3.53 | ± | 0.412 | |||
| 4444 | 25 | 3.82 | ± | 0.527 | |||
| Average | 4.25 | ± | 0.373 | ||||
| Test Chemical | Bisphenol A |
125 |
4436 | 25 | 3.42 | ± | 0.368 |
| 4437 | 25 | 4.59 | ± | 0.529 | |||
| 4438 | 25 | 6.89 | ± | 0.699 | |||
| 4439 | 25 | 4.74 | ± | 0.483 | |||
| Average | 4.91 | ± | 0.723 | ||||
| Test Chemical | Bisphenol A |
250 |
4431 | 25 | 4.08 | ± | 0.476 |
| 4432 | 25 | 5.13 | ± | 0.499 | |||
| 4433 | 25 | 6.43 | ± | 0.497 | |||
| 4434 | 25 | 4.74 | ± | 0.456 | |||
| Average | 5.09 | ± | 0.495 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
4451 | 25 | 10.78 | ± | 1.009 |
| 4452 | 25 | 11.94 | ± | 0.696 | |||
| 4453 | 25 | 9.08 | ± | 1.000 | |||
| 4454 | 25 | 10.08 | ± | 0.950 | |||
| Average | 10.46 | ± | 0.602 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed