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Study Information
Study Attribute Value
CEBS Accession Number: 002-01634-0011-0000-8
Chemical Name: Allyl isovalerate
CASRN: 2835-39-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 070779_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/22/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 11476 50 9 9 0 0 0 0 0 18 0.36 0.18 26.00 14.00
    11488 50 6 7 0 0 0 0 0 13 0.26 0.12 22.00 12.00
    11500 50 6 8 0 0 0 0 0 14 0.28 0.12 22.00 10.00
    11512 50 6 7 0 0 0 0 1 14 0.28 0.14 24.00 12.00
    11524 50 6 13 0 1 0 0 1 21 0.42 0.14 36.00 16.00
    11526 50 7 16 0 1 0 0 0 24 0.48 0.14 40.00 14.00
    11529 50 9 13 0 0 0 0 0 22 0.44 0.18 32.00 16.00
    11541 50 5 7 0 0 0 0 1 13 0.26 0.12 18.00 10.00
Average         6.8 10.0 0.0 0.3 0.0 0.0 0.4 17.4 0.35 0.14 27.50 13.00
± SEM                         0.03 0.01 2.72 0.85
 
Test Chemical Allyl isovalerate 
37.5       
 11511 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11515 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11517 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11536 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11544 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11545 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11546 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11547 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.5 1.4 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.01 3.50 1.00
± SEM                         0.00 0.00 0.33 0.38
 
Test Chemical Allyl isovalerate 
75         
 11513 50 1 4 0 1 0 0 0 6 0.12 0.02 6.00 2.00
    11514 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    11539 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11542 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11548 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11549 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11551 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11552 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 1.0 0.0 0.1 0.0 0.0 0.1 1.8 0.04 0.01 2.50 1.00
± SEM                         0.02 0.01 0.98 0.53
 
Test Chemical Allyl isovalerate 
150         
 11521 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11522 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11525 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11530 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    11534 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    11535 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    11543 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    11550 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
Average         1.0 1.5 0.0 0.0 0.0 0.0 0.1 2.6 0.05 0.02 4.50 2.00
± SEM                         0.02 0.01 1.99 1.25
 
Vehicle Control No Stressor 
 0         
 11479 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11480 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11484 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11498 50 2 4 0 0 0 0 1 7 0.14 0.06 10.00 4.00
    11504 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11506 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11528 50 1 6 0 0 0 0 0 7 0.14 0.02 8.00 2.00
    11537 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.8 2.0 0.0 0.0 0.0 0.0 0.1 2.9 0.06 0.02 4.25 1.50
± SEM                         0.02 0.01 1.22 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation