| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01364-0007-0000-3 |
| Chemical Name: | 2-Naphthylamine |
| CASRN: | 91-59-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 080086_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/21/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
1976 | 24 | 5.37 | ± | 0.540 |
| 1978 | 24 | 5.21 | ± | 0.463 | |||
| 1987 | 24 | 3.71 | ± | 0.412 | |||
| 2000 | 25 | 5.64 | ± | 0.414 | |||
| Average | 5.00 | ± | 0.432 | ||||
| Test Chemical | 2-Naphthylamine |
87.5 |
1981 | 25 | 8.21 | ± | 0.639 |
| 1985 | 25 | 5.41 | ± | 0.472 | |||
| 1989 | 25 | 7.27 | ± | 0.858 | |||
| 1994 | 26 | 6.13 | ± | 0.666 | |||
| Average | 6.76 | ± | 0.617 | ||||
| Test Chemical | 2-Naphthylamine |
175 |
1980 | 24 | 7.03 | ± | 0.676 |
| 1984 | 26 | 6.79 | ± | 0.426 | |||
| 1986 | 24 | 6.54 | ± | 0.819 | |||
| 1998 | 25 | 7.63 | ± | 0.544 | |||
| Average | 7.00 | ± | 0.233 | ||||
| Test Chemical | 2-Naphthylamine |
350 |
1991 | 25 | 11.66 | ± | 1.195 |
| 1992 | 25 | 8.27 | ± | 1.547 | |||
| 1995 | 25 | 10.29 | ± | 0.988 | |||
| 1997 | 25 | 13.71 | ± | 1.268 | |||
| Average | 10.97 | ± | 1.146 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
1977 | 25 | 14.72 | ± | 0.898 |
| 1979 | 25 | 17.59 | ± | 1.503 | |||
| 1990 | 25 | 9.29 | ± | 0.594 | |||
| 1996 | 25 | 13.06 | ± | 1.210 | |||
| Average | 13.66 | ± | 1.732 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed