| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01364-0007-0000-3 |
| Chemical Name: | 2-Naphthylamine |
| CASRN: | 91-59-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 080086_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/02/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
6970 | 25 | 5.84 | ± | 0.501 |
| 6981 | 25 | 5.10 | ± | 0.334 | |||
| 6993 | 25 | 5.43 | ± | 0.490 | |||
| 7004 | 25 | 6.32 | ± | 0.464 | |||
| Average | 5.67 | ± | 0.264 | ||||
| Test Chemical | 2-Naphthylamine |
87.5 |
6967 | 25 | 4.45 | ± | 0.337 |
| 6968 | 24 | 6.48 | ± | 0.390 | |||
| 6975 | 25 | 6.51 | ± | 0.523 | |||
| 6985 | 25 | 4.57 | ± | 0.400 | |||
| Average | 5.49 | ± | 0.573 | ||||
| Test Chemical | 2-Naphthylamine |
175 |
6965 | 25 | 5.59 | ± | 0.431 |
| 6966 | 25 | 10.42 | ± | 0.958 | |||
| 6980 | 25 | 6.23 | ± | 0.572 | |||
| 6984 | 25 | 7.14 | ± | 0.702 | |||
| Average | 7.34 | ± | 1.072 | ||||
| Test Chemical | 2-Naphthylamine |
350 |
6962 | 24 | 5.61 | ± | 0.329 |
| 6963 | 25 | 6.86 | ± | 0.685 | |||
| 6972 | 25 | 8.63 | ± | 0.913 | |||
| 6974 | 25 | 9.15 | ± | 0.788 | |||
| 6979 | 25 | 7.43 | ± | 0.523 | |||
| 6982 | 25 | 8.19 | ± | 0.662 | |||
| 6986 | 25 | 11.98 | ± | 0.993 | |||
| Average | 8.27 | ± | 0.762 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6969 | 25 | 12.86 | ± | 0.989 |
| 6971 | 25 | 14.93 | ± | 1.189 | |||
| 6983 | 25 | 9.39 | ± | 0.548 | |||
| 7000 | 25 | 13.59 | ± | 0.942 | |||
| Average | 12.70 | ± | 1.181 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed