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Study Information
Study Attribute Value
CEBS Accession Number: 002-03239-0003-0000-2
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 097978_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/01/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 9622 50 5 19 0 0 0 0 0 24 0.48 0.10 22.00 10.00
    9623 50 4 16 0 1 0 0 0 21 0.42 0.08 18.00 8.00
    9624 50 9 20 0 0 0 0 0 29 0.58 0.18 24.00 12.00
    9625 50 5 12 1 0 0 0 0 18 0.36 0.12 18.00 10.00
    9626 50 12 29 2 2 0 0 0 45 0.90 0.28 38.00 22.00
    9627 50 3 11 0 1 0 0 0 15 0.30 0.06 18.00 6.00
    9628 50 4 16 1 0 0 0 0 21 0.42 0.10 22.00 6.00
    9629 50 20 16 0 0 0 0 0 36 0.72 0.40 32.00 20.00
Average         7.8 17.4 0.5 0.5 0.0 0.0 0.0 26.1 0.52 0.17 24.00 11.75
± SEM                         0.07 0.04 2.59 2.15
 
Test Chemical DL-menthol 
225         
 9582 50 3 2 1 0 0 0 0 6 0.12 0.08 8.00 6.00
    9583 50 6 1 0 0 0 0 0 7 0.14 0.12 8.00 6.00
    9584 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9585 50 4 1 1 0 0 0 0 6 0.12 0.10 8.00 6.00
    9586 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    9587 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    9588 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9589 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
Average         1.6 1.9 0.4 0.0 0.0 0.0 0.0 3.9 0.08 0.04 5.50 2.50
± SEM                         0.02 0.02 0.98 1.05
 
Test Chemical DL-menthol 
450         
 9592 50 4 3 0 0 0 0 0 7 0.14 0.08 10.00 6.00
    9593 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    9594 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9595 50 1 0 2 0 0 0 0 3 0.06 0.06 6.00 6.00
    9596 50 4 1 0 0 0 0 0 5 0.10 0.08 6.00 6.00
    9597 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    9598 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9599 50 1 0 2 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         1.5 0.6 0.8 0.0 0.0 0.0 0.0 2.9 0.06 0.05 4.75 4.00
± SEM                         0.02 0.01 1.00 0.76
 
Test Chemical DL-menthol 
900         
 9602 50 3 5 0 0 0 0 0 8 0.16 0.06 10.00 6.00
    9603 50 7 6 0 0 0 0 0 13 0.26 0.14 22.00 14.00
    9604 50 7 12 1 0 0 0 0 20 0.40 0.16 28.00 14.00
    9605 50 3 12 1 0 0 0 0 16 0.32 0.08 22.00 6.00
    9606 50 4 18 0 1 0 0 0 23 0.46 0.08 26.00 8.00
    9607 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9608 50 5 8 1 0 0 0 0 14 0.28 0.12 14.00 10.00
    9610 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         4.0 7.8 0.4 0.1 0.0 0.0 0.0 12.3 0.25 0.09 16.00 7.75
± SEM                         0.05 0.02 3.53 1.67
 
Vehicle Control No Stressor 
 0         
 9612 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9613 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    9614 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9615 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9616 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    9617 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9618 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9619 50 2 1 0 1 0 0 0 4 0.08 0.04 8.00 4.00
Average         1.1 1.6 0.0 0.1 0.0 0.0 0.0 2.9 0.06 0.02 5.50 2.00
± SEM                         0.01 0.01 0.63 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation