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Study Information
Study Attribute Value
CEBS Accession Number: 002-03239-0003-0000-2
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 097978_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/15/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12085 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12086 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    12087 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    12089 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    12090 50 3 3 1 0 0 0 0 7 0.14 0.08 14.00 8.00
    12091 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    12092 50 10 2 1 0 0 0 0 13 0.26 0.22 18.00 16.00
    12093 50 9 0 0 0 0 0 1 10 0.20 0.20 14.00 14.00
Average         4.5 1.6 0.4 0.0 0.0 0.0 0.1 6.6 0.13 0.10 11.50 8.50
± SEM                         0.03 0.03 1.95 1.76
 
Test Chemical DL-menthol 
450         
 12045 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12046 50 1 2 0 0 0 0 1 4 0.08 0.04 8.00 4.00
    12047 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12049 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12050 50 2 2 1 0 0 0 0 5 0.10 0.06 10.00 6.00
    12051 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12052 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12053 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.0 0.8 0.1 0.0 0.0 0.0 0.1 2.0 0.04 0.03 4.00 2.50
± SEM                         0.01 0.01 1.25 0.73
 
Test Chemical DL-menthol 
675         
 12055 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    12056 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12057 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    12058 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12059 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12060 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12061 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12062 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         1.3 0.8 0.1 0.0 0.0 0.0 0.0 2.1 0.04 0.03 4.00 2.75
± SEM                         0.01 0.01 0.85 0.65
 
Test Chemical DL-menthol 
900         
 12065 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    12066 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12067 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12069 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12070 50 0 3 0 0 0 0 1 4 0.08 0.02 6.00 0.00
    12071 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12072 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12073 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         1.0 1.1 0.0 0.0 0.0 0.0 0.1 2.3 0.05 0.02 4.25 2.00
± SEM                         0.01 0.01 0.96 0.85
 
Vehicle Control No Stressor 
 0         
 12075 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
    12076 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12077 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    12078 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12079 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    12080 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12081 50 3 4 0 0 0 0 0 7 0.14 0.06 14.00 6.00
Average         2.4 1.0 0.0 0.0 0.0 0.0 0.0 3.4 0.07 0.05 6.29 4.57
± SEM                         0.02 0.02 1.82 1.43
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation