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Study Information
Study Attribute Value
CEBS Accession Number: 002-03239-0003-0000-2
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 097978_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/12/1992 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 12820 50 36 7 1 0 0 0 0 44 0.88 0.74 30.00 20.00
    12821 50 37 4 0 0 0 0 0 41 0.82 0.74 24.00 16.00
    12822 50 48 10 1 0 0 0 0 59 1.18 0.98 38.00 26.00
    12823 50 28 7 0 0 0 0 1 36 0.72 0.58 30.00 28.00
    12824 50 28 7 0 0 0 0 0 35 0.70 0.56 16.00 12.00
    12825 50 78 3 0 0 0 0 0 81 1.62 1.56 32.00 32.00
    12827 50 64 4 0 0 0 0 0 68 1.36 1.28 24.00 18.00
    12828 50 46 5 0 0 0 0 0 51 1.02 0.92 28.00 20.00
Average         45.6 5.9 0.3 0.0 0.0 0.0 0.1 51.9 1.04 0.92 27.75 21.50
± SEM                         0.12 0.12 2.31 2.35
 
Test Chemical DL-menthol 
225         
 12780 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12781 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12782 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12783 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12784 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12785 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12786 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12787 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.25
± SEM                         0.01 0.01 0.70 0.65
 
Test Chemical DL-menthol 
450         
 12790 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12791 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12792 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12793 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12794 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12795 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12796 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12797 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.5 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.50 1.50
± SEM                         0.01 0.01 0.91 0.63
 
Test Chemical DL-menthol 
900         
 12800 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    12801 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12802 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12803 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12804 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12805 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12806 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    12807 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.6 0.6 0.0 0.1 0.0 0.0 0.0 2.4 0.05 0.03 4.25 2.75
± SEM                         0.01 0.01 0.88 0.75
 
Vehicle Control No Stressor 
 0         
 12810 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12811 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12812 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12813 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12814 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12815 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12816 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12817 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.75 1.00
± SEM                         0.01 0.01 0.45 0.38
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation