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Study Information
Study Attribute Value
CEBS Accession Number: 002-03239-0003-0000-2
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 097978_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/09/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13521 50 43 11 0 0 0 0 0 54 1.08 0.86 40.00 30.00
    13522 50 32 9 1 0 0 0 0 42 0.84 0.66 30.00 22.00
    13523 50 31 3 0 2 0 0 1 37 0.74 0.64 32.00 26.00
    13525 50 71 2 0 0 0 0 1 74 1.48 1.44 20.00 18.00
    13526 50 56 6 0 0 0 0 2 64 1.28 1.16 38.00 30.00
    13527 50 33 11 1 0 0 0 0 45 0.90 0.68 36.00 24.00
    13528 50 38 10 0 0 0 0 0 48 0.96 0.76 34.00 28.00
    13529 50 20 9 0 0 0 0 0 29 0.58 0.40 24.00 18.00
Average         40.5 7.6 0.3 0.3 0.0 0.0 0.5 49.1 0.98 0.83 31.75 24.50
± SEM                         0.10 0.12 2.43 1.72
 
Test Chemical DL-menthol 
225         
 13481 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13482 50 1 1 1 0 0 0 0 3 0.06 0.04 4.00 4.00
    13483 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    13484 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13485 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    13486 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13487 50 2 4 0 0 0 0 0 6 0.12 0.04 8.00 4.00
    13488 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 1.0 0.3 0.0 0.0 0.0 0.0 2.4 0.05 0.03 4.00 2.75
± SEM                         0.01 0.01 0.85 0.65
 
Test Chemical DL-menthol 
450         
 13490 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13492 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    13493 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13494 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13495 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13496 50 4 0 0 0 0 0 1 5 0.10 0.10 10.00 10.00
    13497 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13498 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.5 0.9 0.0 0.0 0.0 0.0 0.1 2.5 0.05 0.03 5.00 3.25
± SEM                         0.01 0.01 1.25 1.06
 
Test Chemical DL-menthol 
900         
 13500 50 8 0 1 0 0 0 0 9 0.18 0.18 6.00 6.00
    13501 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13502 50 2 1 2 0 0 0 0 5 0.10 0.08 8.00 8.00
    13503 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 8.00
    13504 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    13506 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13507 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
Average         3.7 1.0 0.4 0.0 0.0 0.0 0.0 5.1 0.10 0.08 7.71 6.00
± SEM                         0.02 0.02 1.02 0.87
 
Vehicle Control No Stressor 
 0         
 13511 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13512 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13513 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    13514 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13516 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13517 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13518 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13519 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.0 0.4 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.50 3.75
± SEM                         0.01 0.01 0.63 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation