| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03239-0002-0000-1 |
| Chemical Name: | DL-menthol |
| CASRN: | 89-78-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 097978_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/08/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6663 | 25 | 4.91 | ± | 0.528 |
| 6664 | 25 | 3.41 | ± | 0.427 | |||
| 6665 | 25 | 3.65 | ± | 0.325 | |||
| 6666 | 25 | 4.34 | ± | 0.353 | |||
| Average | 4.08 | ± | 0.341 | ||||
| Test Chemical | DL-menthol |
225 |
6648 | 25 | 3.31 | ± | 0.415 |
| 6649 | 25 | 3.85 | ± | 0.393 | |||
| 6650 | 25 | 3.50 | ± | 0.318 | |||
| 6651 | 25 | 4.57 | ± | 0.355 | |||
| Average | 3.81 | ± | 0.277 | ||||
| Test Chemical | DL-menthol |
450 |
6653 | 25 | 4.54 | ± | 0.389 |
| 6655 | 25 | 2.26 | ± | 0.275 | |||
| 6656 | 25 | 3.65 | ± | 0.380 | |||
| 6657 | 25 | 3.14 | ± | 0.346 | |||
| Average | 3.40 | ± | 0.478 | ||||
| Test Chemical | DL-menthol |
900 |
6658 | 25 | 4.81 | ± | 0.494 |
| 6659 | 25 | 6.08 | ± | 0.665 | |||
| 6660 | 25 | 2.72 | ± | 0.268 | |||
| 6662 | 25 | 4.34 | ± | 0.523 | |||
| Average | 4.48 | ± | 0.694 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6668 | 25 | 4.94 | ± | 0.421 |
| 6669 | 25 | 4.69 | ± | 0.409 | |||
| 6670 | 25 | 5.86 | ± | 0.505 | |||
| 6671 | 25 | 6.85 | ± | 0.548 | |||
| Average | 5.59 | ± | 0.490 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed