Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02706-0009-0000-6
Chemical Name:	Polybrominated biphenyl mixture (Firemaster FF-1)
CASRN:	67774-32-7
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	103512_CA
Study Result:	Negative

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Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.

Initial Treatment Date	Tissue	Sample Time (h)	Sex	Species	Strain	Protocol	Result
02/01/1989	Bone Marrow	17	Male	Mouse	B6C3F1	Intraperitoneal Injection x 1/study, 17 hour	Negative

		Dose (mg/kg)	Animal Number	No. Cells	Chromatid		Isochromatid		Exchanges			Aberrations
					Breaks	Gaps	Breaks	Gaps	'Tid	'Some	Other	Total	Per Cell		% Cells w/ Abs
					Breaks	Gaps	Breaks	Gaps	'Tid	'Some	Other	Total	(+ Gaps)	(- Gaps)	(+ Gaps)	(- Gaps)
Positive Control	Dimethylbenzanthracene	100	9622	50	5	19	0	0	0	0	0	24	0.48	0.10	22.00	10.00
			9623	50	4	16	0	1	0	0	0	21	0.42	0.08	18.00	8.00
			9624	50	9	20	0	0	0	0	0	29	0.58	0.18	24.00	12.00
			9625	50	5	12	1	0	0	0	0	18	0.36	0.12	18.00	10.00
			9626	50	12	29	2	2	0	0	0	45	0.90	0.28	38.00	22.00
			9627	50	3	11	0	1	0	0	0	15	0.30	0.06	18.00	6.00
			9628	50	4	16	1	0	0	0	0	21	0.42	0.10	22.00	6.00
			9629	50	20	16	0	0	0	0	0	36	0.72	0.40	32.00	20.00
Average					7.8	17.4	0.5	0.5	0.0	0.0	0.0	26.1	0.52	0.17	24.00	11.75
± SEM													0.07	0.04	2.59	2.15

Test Chemical	Polybrominated biphenyl mixture (Firemaster FF-1)	1250	9552	50	0	1	0	0	0	0	0	1	0.02	0.00	2.00	0.00
			9553	50	3	1	0	0	0	0	1	5	0.10	0.08	8.00	8.00
			9554	50	0	0	0	0	0	0	0	0	0.00	0.00	0.00	0.00
			9555	50	2	1	0	0	0	0	0	3	0.06	0.04	4.00	2.00
			9556	50	4	0	0	0	0	0	0	4	0.08	0.08	4.00	4.00
			9557	50	1	0	0	0	0	0	0	1	0.02	0.02	2.00	2.00
			9558	50	9	1	0	0	0	0	0	10	0.20	0.18	12.00	10.00
			9559	50	18	1	0	0	0	0	0	19	0.38	0.36	18.00	18.00
Average					4.6	0.6	0.0	0.0	0.0	0.0	0.1	5.4	0.11	0.10	6.25	5.50
± SEM													0.04	0.04	2.15	2.20

Test Chemical	Polybrominated biphenyl mixture (Firemaster FF-1)	2500	9562	50	1	1	2	0	0	0	0	4	0.08	0.06	6.00	4.00
			9563	50	10	2	0	0	0	0	0	12	0.24	0.20	16.00	12.00
			9564	50	6	0	1	0	0	0	0	7	0.14	0.14	8.00	8.00
			9565	50	2	1	0	0	0	0	0	3	0.06	0.04	4.00	2.00
			9566	50	5	1	0	0	0	0	0	6	0.12	0.10	8.00	6.00
			9567	50	12	9	2	0	0	0	0	23	0.46	0.28	24.00	14.00
			9568	50	1	1	0	0	0	0	0	2	0.04	0.02	4.00	2.00
			9569	50	5	1	1	0	0	0	0	7	0.14	0.12	8.00	8.00
Average					5.3	2.0	0.8	0.0	0.0	0.0	0.0	8.0	0.16	0.12	9.75	7.00
± SEM													0.05	0.03	2.43	1.56

Test Chemical	Polybrominated biphenyl mixture (Firemaster FF-1)	5000	9572	50	2	1	0	0	0	0	1	4	0.08	0.06	4.00	2.00
			9573	50	0	1	0	0	0	0	0	1	0.02	0.00	2.00	0.00
			9574	50	2	0	1	0	0	0	0	3	0.06	0.06	4.00	4.00
			9575	50	0	0	0	0	0	0	0	0	0.00	0.00	0.00	0.00
			9576	50	1	0	1	0	0	0	0	2	0.04	0.04	4.00	4.00
			9577	50	1	4	0	0	0	0	0	5	0.10	0.02	10.00	2.00
			9578	50	1	0	0	0	0	0	0	1	0.02	0.02	2.00	2.00
			9580	50	6	2	0	1	0	0	0	9	0.18	0.12	10.00	6.00
Average					1.6	1.0	0.3	0.1	0.0	0.0	0.1	3.1	0.06	0.04	4.50	2.50
± SEM													0.02	0.01	1.30	0.73

Vehicle Control	No Stressor	0	9612	50	1	1	0	0	0	0	0	2	0.04	0.02	4.00	2.00
			9613	50	2	1	0	0	0	0	0	3	0.06	0.04	4.00	2.00
			9614	50	0	2	0	0	0	0	0	2	0.04	0.00	4.00	0.00
			9615	50	2	1	0	0	0	0	0	3	0.06	0.04	6.00	4.00
			9616	50	1	3	0	0	0	0	0	4	0.08	0.02	8.00	2.00
			9617	50	0	3	0	0	0	0	0	3	0.06	0.00	6.00	0.00
			9618	50	1	1	0	0	0	0	0	2	0.04	0.02	4.00	2.00
			9619	50	2	1	0	1	0	0	0	4	0.08	0.04	8.00	4.00
Average					1.1	1.6	0.0	0.1	0.0	0.0	0.0	2.9	0.06	0.02	5.50	2.00
± SEM													0.01	0.01	0.63	0.53

Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation