| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02706-0009-0000-6 |
| Chemical Name: | Polybrominated biphenyl mixture (Firemaster FF-1) |
| CASRN: | 67774-32-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 103512_CA |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 12/08/1992 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 36 hour | Negative |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Positive Control | Dimethylbenzanthracene |
50 |
13274 | 50 | 61 | 9 | 1 | 0 | 0 | 0 | 1 | 72 | 1.44 | 1.26 | 42.00 | 30.00 |
| 13275 | 50 | 21 | 8 | 1 | 0 | 0 | 0 | 0 | 30 | 0.60 | 0.44 | 38.00 | 32.00 | |||
| 13276 | 50 | 57 | 12 | 0 | 0 | 0 | 0 | 0 | 69 | 1.38 | 1.14 | 42.00 | 32.00 | |||
| 13277 | 50 | 148 | 11 | 2 | 0 | 0 | 0 | 0 | 161 | 3.22 | 3.00 | 58.00 | 54.00 | |||
| 13278 | 50 | 84 | 9 | 0 | 0 | 0 | 0 | 0 | 93 | 1.86 | 1.68 | 38.00 | 34.00 | |||
| 13279 | 50 | 58 | 8 | 1 | 0 | 0 | 0 | 2 | 69 | 1.38 | 1.22 | 30.00 | 24.00 | |||
| 13280 | 50 | 115 | 14 | 1 | 0 | 0 | 0 | 0 | 130 | 2.60 | 2.32 | 52.00 | 42.00 | |||
| 13281 | 50 | 78 | 8 | 4 | 1 | 0 | 0 | 2 | 93 | 1.86 | 1.68 | 46.00 | 40.00 | |||
| Average | 77.8 | 9.9 | 1.3 | 0.1 | 0.0 | 0.0 | 0.6 | 89.6 | 1.79 | 1.59 | 43.25 | 36.00 | ||||
| ± SEM | 0.29 | 0.28 | 3.09 | 3.25 | ||||||||||||
| Test Chemical | Polybrominated biphenyl mixture (Firemaster FF-1) |
1250 |
13206 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 13207 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13208 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
| 13209 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
| 13210 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
| 13211 | 50 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
| 13212 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| Average | 1.0 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.4 | 0.03 | 0.02 | 2.86 | 2.00 | ||||
| ± SEM | 0.01 | 0.01 | 1.14 | 0.76 | ||||||||||||
| Test Chemical | Polybrominated biphenyl mixture (Firemaster FF-1) |
2500 |
13214 | 50 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.10 | 6.00 | 6.00 |
| 13215 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
| 13216 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13217 | 50 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13218 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| 13219 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
| 13220 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| 13221 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| Average | 1.0 | 0.6 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 1.8 | 0.04 | 0.02 | 3.00 | 1.75 | ||||
| ± SEM | 0.01 | 0.01 | 0.76 | 0.80 | ||||||||||||
| Test Chemical | Polybrominated biphenyl mixture (Firemaster FF-1) |
5000 |
13224 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 |
| 13225 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| 13226 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 | |||
| 13227 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13228 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13229 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13230 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13231 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 2.00 | 2.00 | |||
| Average | 1.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | 0.03 | 0.02 | 2.25 | 2.00 | ||||
| ± SEM | 0.01 | 0.01 | 0.59 | 0.65 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
13264 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 13265 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13266 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13267 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13268 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 13269 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 13270 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
| 13271 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| Average | 0.4 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.5 | 0.01 | 0.01 | 1.00 | 0.75 | ||||
| ± SEM | 0.01 | 0.00 | 0.53 | 0.37 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation