| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01812-0012-0000-7 |
| Chemical Name: | C.I. Solvent yellow 14 |
| CASRN: | 842-07-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 114547_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/30/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
9208 | 25 | 4.69 | ± | 0.527 |
| 9209 | 25 | 4.68 | ± | 0.438 | |||
| 9210 | 25 | 3.76 | ± | 0.507 | |||
| 9211 | 25 | 2.81 | ± | 0.409 | |||
| Average | 3.99 | ± | 0.449 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
875 |
9193 | 25 | 4.92 | ± | 0.486 |
| 9194 | 25 | 4.76 | ± | 0.551 | |||
| 9195 | 25 | 4.96 | ± | 0.643 | |||
| 9196 | 25 | 5.21 | ± | 0.473 | |||
| Average | 4.97 | ± | 0.093 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
1750 |
9198 | 25 | 6.28 | ± | 0.604 |
| 9199 | 25 | 4.93 | ± | 0.519 | |||
| 9200 | 25 | 4.53 | ± | 0.356 | |||
| 9202 | 25 | 5.68 | ± | 0.468 | |||
| Average | 5.36 | ± | 0.390 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
3500 |
9203 | 25 | 4.56 | ± | 0.459 |
| 9204 | 25 | 7.44 | ± | 0.633 | |||
| 9205 | 25 | 5.16 | ± | 0.492 | |||
| 9206 | 25 | 6.72 | ± | 0.725 | |||
| Average | 5.97 | ± | 0.669 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
9213 | 25 | 6.81 | ± | 0.707 |
| 9214 | 25 | 8.48 | ± | 0.870 | |||
| 9215 | 25 | 6.80 | ± | 0.785 | |||
| 9216 | 25 | 7.77 | ± | 0.931 | |||
| Average | 7.47 | ± | 0.408 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed