| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01812-0012-0000-7 |
| Chemical Name: | C.I. Solvent yellow 14 |
| CASRN: | 842-07-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 114547_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/31/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10460 | 25 | 4.66 | ± | 0.494 |
| 10461 | 25 | 4.28 | ± | 0.434 | |||
| 10462 | 25 | 3.33 | ± | 0.473 | |||
| 10463 | 25 | 4.22 | ± | 0.477 | |||
| Average | 4.12 | ± | 0.282 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
1750 |
10445 | 25 | 8.30 | ± | 0.626 |
| 10446 | 25 | 6.09 | ± | 0.509 | |||
| 10447 | 25 | 5.14 | ± | 0.535 | |||
| 10448 | 25 | 5.77 | ± | 0.488 | |||
| Average | 6.32 | ± | 0.687 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
2625 |
10450 | 25 | 6.12 | ± | 0.533 |
| 10451 | 25 | 11.59 | ± | 1.381 | |||
| 10452 | 25 | 7.29 | ± | 0.719 | |||
| 10453 | 25 | 7.01 | ± | 0.450 | |||
| Average | 8.00 | ± | 1.222 | ||||
| Test Chemical | C.I. Solvent yellow 14 |
3500 |
10455 | 25 | 5.88 | ± | 0.541 |
| 10456 | 25 | 6.72 | ± | 0.745 | |||
| 10457 | 25 | 6.48 | ± | 0.771 | |||
| 10459 | 25 | 7.23 | ± | 0.664 | |||
| Average | 6.57 | ± | 0.281 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10465 | 25 | 6.01 | ± | 0.800 |
| 10466 | 25 | 9.65 | ± | 1.004 | |||
| 10467 | 25 | 11.43 | ± | 0.845 | |||
| 10468 | 25 | 8.49 | ± | 0.609 | |||
| Average | 8.90 | ± | 1.134 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed