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Study Information
Study Attribute Value
CEBS Accession Number: 002-02202-0013-0000-2
Chemical Name: Geranyl acetate
CASRN: 105-87-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 125080_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/03/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6315 50 13 33 0 2 0 0 0 48 0.96 0.26 52.00 20.00
    6316 50 8 17 3 0 0 0 0 28 0.56 0.22 36.00 20.00
    6317 50 10 11 0 0 0 0 0 21 0.42 0.20 22.00 14.00
    6318 50 7 21 0 0 0 0 1 29 0.58 0.16 32.00 12.00
    6319 50 15 48 0 0 0 0 0 63 1.26 0.30 46.00 20.00
    6320 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 2.00
    6321 50 9 16 0 0 0 0 0 25 0.50 0.18 34.00 16.00
    6322 50 6 18 1 0 0 0 0 25 0.50 0.14 26.00 12.00
Average         8.6 21.1 0.5 0.3 0.0 0.0 0.1 30.6 0.61 0.19 32.25 14.50
± SEM                         0.12 0.03 4.70 2.16
 
Test Chemical Geranyl acetate 
425         
 6245 50 4 1 1 0 0 0 0 6 0.12 0.10 12.00 10.00
    6246 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    6247 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6248 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    6250 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    6251 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    6252 50 2 2 0 1 0 0 0 5 0.10 0.04 10.00 4.00
    6253 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         2.3 1.4 0.1 0.1 0.0 0.0 0.0 3.9 0.08 0.05 7.25 4.25
± SEM                         0.01 0.01 1.13 1.03
 
Test Chemical Geranyl acetate 
850         
 6255 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    6256 50 3 6 0 0 0 0 0 9 0.18 0.06 14.00 4.00
    6257 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6258 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    6259 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    6260 50 0 4 0 1 0 0 0 5 0.10 0.00 4.00 0.00
    6261 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    6262 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 2.8 0.0 0.1 0.0 0.0 0.0 3.6 0.07 0.02 5.50 1.25
± SEM                         0.02 0.01 1.40 0.53
 
Test Chemical Geranyl acetate 
1700         
 6265 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 10.00
    6266 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    6267 50 1 3 2 0 0 0 0 6 0.12 0.06 12.00 6.00
    6268 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    6269 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6270 50 1 6 0 0 0 0 0 7 0.14 0.02 10.00 2.00
    6271 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    6272 50 5 5 0 0 0 0 0 10 0.20 0.10 18.00 10.00
Average         2.8 3.1 0.3 0.0 0.0 0.0 0.0 6.1 0.12 0.06 11.00 5.75
± SEM                         0.02 0.01 1.73 1.33
 
Vehicle Control No Stressor 
 0         
 6305 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6306 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    6307 50 1 6 0 0 0 0 0 7 0.14 0.02 8.00 2.00
    6308 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    6309 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    6310 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    6311 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6312 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.0 1.9 0.0 0.0 0.0 0.0 0.0 2.9 0.06 0.02 4.50 2.00
± SEM                         0.02 0.01 1.18 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation