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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0012-0000-4
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 135008_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/09/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9375 50 17 7 0 0 0 0 1 25 0.50 0.36 20.00 14.00
    9381 50 24 9 1 0 0 0 0 34 0.68 0.50 22.00 12.00
    9391 50 4 7 0 1 0 0 0 12 0.24 0.08 22.00 8.00
    9398 50 40 12 0 0 0 2 0 54 1.08 0.84 38.00 20.00
    9404 50 21 12 0 0 0 0 0 33 0.66 0.42 32.00 20.00
    9410 50 20 16 0 0 0 0 0 36 0.72 0.40 36.00 22.00
    9435 50 16 6 0 0 0 0 0 22 0.44 0.32 22.00 14.00
    9451 50 59 8 0 0 0 0 0 67 1.34 1.18 34.00 26.00
Average         25.1 9.6 0.1 0.1 0.0 0.3 0.1 35.4 0.71 0.51 28.25 17.00
± SEM                         0.13 0.12 2.63 2.10
 
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 9366 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9368 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 4.00
    9373 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    9382 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9383 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    9394 50 1 1 0 1 0 0 0 3 0.06 0.02 6.00 2.00
    9395 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9399 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.6 1.4 0.0 0.1 0.0 0.0 0.1 2.3 0.05 0.02 4.50 1.50
± SEM                         0.01 0.01 0.73 0.50
 
Test Chemical tris(2-Ethylhexyl)phosphate 
2500         
 9367 50 1 1 0 0 0 0 1 3 0.06 0.04 6.00 4.00
    9370 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9372 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 4.00
    9377 50 0 3 0 0 0 0 1 4 0.08 0.02 4.00 0.00
    9384 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9389 50 0 3 0 0 0 0 1 4 0.08 0.02 6.00 0.00
    9390 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9392 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
Average         0.6 2.0 0.0 0.0 0.0 0.0 0.4 3.0 0.06 0.02 5.25 1.75
± SEM                         0.01 0.01 0.92 0.70
 
Test Chemical tris(2-Ethylhexyl)phosphate 
5000         
 9364 50 1 4 1 0 0 0 0 6 0.12 0.04 10.00 4.00
    9369 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    9371 50 3 0 0 0 0 0 1 4 0.08 0.08 6.00 6.00
    9376 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    9379 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    9380 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    9385 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    9388 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.3 1.9 0.3 0.0 0.0 0.0 0.3 3.6 0.07 0.04 6.25 3.00
± SEM                         0.01 0.01 0.88 0.65
 
Vehicle Control No Stressor 
 0         
 9365 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    9374 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    9378 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9409 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9412 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    9429 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9438 50 0 5 0 1 0 0 0 6 0.12 0.00 8.00 0.00
    9455 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
Average         1.4 1.6 0.0 0.1 0.0 0.0 0.3 3.4 0.07 0.03 5.25 2.75
± SEM                         0.01 0.01 0.65 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation