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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0012-0000-4
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 135008_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/29/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 10092 50 8 6 0 0 0 0 0 14 0.28 0.16 26.00 14.00
    10094 50 3 8 0 0 0 0 1 12 0.24 0.08 14.00 6.00
    10102 50 5 6 0 0 0 0 1 12 0.24 0.12 16.00 8.00
    10109 50 8 4 0 1 0 0 0 13 0.26 0.16 20.00 12.00
    10120 50 11 7 0 0 0 0 0 18 0.36 0.22 24.00 18.00
    10127 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 4.00
    10143 50 10 7 0 0 0 0 1 18 0.36 0.22 24.00 12.00
    10167 50 5 5 0 0 0 0 0 10 0.20 0.10 18.00 10.00
Average         6.6 5.8 0.0 0.1 0.0 0.0 0.4 12.9 0.26 0.14 19.00 10.50
± SEM                         0.03 0.02 1.96 1.59
 
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 10086 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10093 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10108 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10119 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10121 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10122 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10125 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10129 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 1.0 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 3.00 1.00
± SEM                         0.01 0.01 0.65 0.76
 
Test Chemical tris(2-Ethylhexyl)phosphate 
2500         
 10091 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10096 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10098 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10099 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    10101 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10113 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10124 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10126 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.9 1.4 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.02 4.50 1.75
± SEM                         0.01 0.01 0.82 0.59
 
Test Chemical tris(2-Ethylhexyl)phosphate 
5000         
 10088 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10097 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    10100 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10103 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10105 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10106 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10118 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10123 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 1.5 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.02 4.50 1.50
± SEM                         0.00 0.01 0.50 0.63
 
Vehicle Control No Stressor 
 0         
 10085 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10107 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10110 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10112 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10116 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    10150 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10159 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.1 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.01 3.25 1.25
± SEM                         0.01 0.01 1.00 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation