| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03222-0011-0000-3 |
| Chemical Name: | tris(2-Ethylhexyl)phosphate |
| CASRN: | 78-42-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 135008_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/26/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
9233 | 25 | 5.72 | ± | 0.448 |
| 9240 | 25 | 5.96 | ± | 0.506 | |||
| 9251 | 25 | 5.17 | ± | 0.428 | |||
| 9270 | 24 | 6.10 | ± | 0.479 | |||
| Average | 5.73 | ± | 0.205 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
1250 |
9232 | 25 | 5.63 | ± | 0.410 |
| 9239 | 25 | 5.93 | ± | 0.546 | |||
| 9243 | 25 | 7.28 | ± | 0.485 | |||
| 9244 | 25 | 9.65 | ± | 1.041 | |||
| Average | 7.13 | ± | 0.915 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
2500 |
9231 | 24 | 4.77 | ± | 0.376 |
| 9235 | 25 | 6.75 | ± | 0.633 | |||
| 9241 | 25 | 8.19 | ± | 0.716 | |||
| 9242 | 25 | 8.26 | ± | 0.603 | |||
| Average | 7.02 | ± | 0.818 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
5000 |
9234 | 25 | 6.47 | ± | 0.785 |
| 9237 | 24 | 7.69 | ± | 0.613 | |||
| 9238 | 25 | 7.34 | ± | 0.643 | |||
| 9246 | 25 | 7.33 | ± | 0.526 | |||
| Average | 7.21 | ± | 0.259 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
9236 | 25 | 12.22 | ± | 0.824 |
| 9245 | 25 | 14.92 | ± | 1.231 | |||
| 9255 | 25 | 14.02 | ± | 0.909 | |||
| 9266 | 25 | 14.95 | ± | 1.299 | |||
| Average | 14.04 | ± | 0.641 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed