| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03222-0011-0000-3 |
| Chemical Name: | tris(2-Ethylhexyl)phosphate |
| CASRN: | 78-42-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 135008_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/12/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10248 | 25 | 4.33 | ± | 0.539 |
| 10249 | 25 | 3.70 | ± | 0.387 | |||
| 10269 | 24 | 4.40 | ± | 0.388 | |||
| 10271 | 25 | 4.94 | ± | 0.433 | |||
| Average | 4.36 | ± | 0.253 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
1250 |
10240 | 24 | 5.77 | ± | 0.448 |
| 10242 | 25 | 4.28 | ± | 0.427 | |||
| 10253 | 24 | 3.64 | ± | 0.451 | |||
| 10254 | 23 | 4.63 | ± | 0.543 | |||
| Average | 4.56 | ± | 0.448 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
2500 |
10246 | 24 | 5.11 | ± | 0.553 |
| 10252 | 25 | 4.87 | ± | 0.477 | |||
| 10255 | 25 | 4.84 | ± | 0.422 | |||
| 10257 | 25 | 7.01 | ± | 0.634 | |||
| Average | 5.47 | ± | 0.521 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
5000 |
10241 | 25 | 5.79 | ± | 0.615 |
| 10244 | 24 | 4.91 | ± | 0.356 | |||
| 10250 | 25 | 5.22 | ± | 0.366 | |||
| 10251 | 24 | 5.13 | ± | 0.538 | |||
| Average | 5.27 | ± | 0.188 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10245 | 25 | 9.58 | ± | 0.796 |
| 10256 | 25 | 9.67 | ± | 0.773 | |||
| 10261 | 25 | 8.59 | ± | 0.660 | |||
| 10273 | 25 | 9.44 | ± | 1.012 | |||
| Average | 9.30 | ± | 0.248 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed