| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03222-0011-0000-3 |
| Chemical Name: | tris(2-Ethylhexyl)phosphate |
| CASRN: | 78-42-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 135008_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/05/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10835 | 24 | 3.22 | ± | 0.318 |
| 10842 | 25 | 3.88 | ± | 0.343 | |||
| 10848 | 25 | 4.02 | ± | 0.304 | |||
| 10856 | 24 | 3.01 | ± | 0.273 | |||
| Average | 3.54 | ± | 0.247 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
3750 |
10849 | 25 | 4.74 | ± | 0.380 |
| 10855 | 25 | 3.54 | ± | 0.354 | |||
| 10858 | 25 | 3.61 | ± | 0.454 | |||
| 10864 | 26 | 3.97 | ± | 0.311 | |||
| Average | 3.96 | ± | 0.275 | ||||
| Test Chemical | tris(2-Ethylhexyl)phosphate |
5000 |
10853 | 25 | 4.58 | ± | 0.699 |
| 10857 | 25 | 4.03 | ± | 0.404 | |||
| 10862 | 25 | 3.13 | ± | 0.295 | |||
| 10863 | 25 | 3.03 | ± | 0.255 | |||
| Average | 3.70 | ± | 0.373 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10826 | 25 | 9.41 | ± | 0.536 |
| 10831 | 25 | 6.40 | ± | 0.792 | |||
| 10845 | 25 | 11.27 | ± | 0.786 | |||
| 10860 | 25 | 7.22 | ± | 0.459 | |||
| Average | 8.57 | ± | 1.101 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed