| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02395-0030-0000-4 |
| Chemical Name: | Melphalan |
| CASRN: | 148-82-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 141321_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/07/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1771 | 25 | 5.08 | ± | 0.445 |
| 1775 | 24 | 4.52 | ± | 0.469 | |||
| 1779 | 25 | 9.18 | ± | 1.063 | |||
| 1786 | 25 | 5.05 | ± | 0.606 | |||
| Average | 5.97 | ± | 1.083 | ||||
| Test Chemical | Melphalan |
0.25 |
1772 | 25 | 9.33 | ± | 0.853 |
| 1778 | 25 | 8.46 | ± | 0.964 | |||
| 1788 | 25 | 18.45 | ± | 1.234 | |||
| 1789 | 25 | 14.50 | ± | 3.758 | |||
| Average | 12.70 | ± | 2.340 | ||||
| Test Chemical | Melphalan |
0.5 |
1776 | 25 | 16.95 | ± | 1.223 |
| 1782 | 25 | 29.23 | ± | 1.763 | |||
| 1784 | 25 | 27.19 | ± | 2.060 | |||
| 1790 | 25 | 16.84 | ± | 1.000 | |||
| Average | 22.55 | ± | 3.292 | ||||
| Test Chemical | Melphalan |
1 |
1777 | 25 | 43.18 | ± | 2.006 |
| 1781 | 25 | 32.71 | ± | 1.935 | |||
| 1783 | 25 | 61.28 | ± | 3.658 | |||
| 1785 | 25 | 21.83 | ± | 1.342 | |||
| Average | 39.80 | ± | 8.396 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
1773 | 25 | 6.66 | ± | 0.573 |
| 1774 | 25 | 12.01 | ± | 0.822 | |||
| 1780 | 26 | 8.57 | ± | 0.623 | |||
| 1787 | 25 | 8.10 | ± | 1.129 | |||
| Average | 8.83 | ± | 1.134 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed