| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01867-0012-0000-7 |
| Chemical Name: | Chloroform |
| CASRN: | 67-66-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 142011_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/30/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2317 | 24 | 4.69 | ± | 0.477 |
| 2320 | 25 | 5.77 | ± | 0.756 | |||
| 2323 | 25 | 6.08 | ± | 0.415 | |||
| 2330 | 23 | 5.35 | ± | 0.502 | |||
| Average | 5.48 | ± | 0.302 | ||||
| Test Chemical | Chloroform |
50 |
2325 | 25 | 5.24 | ± | 0.353 |
| 2337 | 25 | 4.65 | ± | 0.539 | |||
| 2342 | 25 | 5.04 | ± | 0.471 | |||
| 2343 | 25 | 5.09 | ± | 0.590 | |||
| Average | 5.01 | ± | 0.125 | ||||
| Test Chemical | Chloroform |
100 |
2319 | 25 | 5.41 | ± | 0.579 |
| 2328 | 25 | 5.24 | ± | 0.503 | |||
| 2329 | 24 | 5.17 | ± | 0.418 | |||
| 2341 | 25 | 5.68 | ± | 0.400 | |||
| Average | 5.38 | ± | 0.114 | ||||
| Test Chemical | Chloroform |
200 |
2321 | 25 | 10.28 | ± | 1.130 |
| 2334 | 25 | 4.71 | ± | 0.342 | |||
| 2336 | 25 | 12.58 | ± | 0.904 | |||
| 2340 | 24 | 7.00 | ± | 0.777 | |||
| Average | 8.66 | ± | 1.742 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2318 | 25 | 6.30 | ± | 0.458 |
| 2322 | 25 | 14.33 | ± | 1.559 | |||
| 2331 | 25 | 14.39 | ± | 1.375 | |||
| 2335 | 25 | 6.49 | ± | 0.711 | |||
| Average | 10.37 | ± | 2.301 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed