| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01867-0012-0000-7 |
| Chemical Name: | Chloroform |
| CASRN: | 67-66-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 142011_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/05/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2344 | 24 | 5.28 | ± | 0.629 |
| 2356 | 25 | 6.26 | ± | 0.423 | |||
| 2367 | 25 | 3.75 | ± | 0.379 | |||
| 2384 | 25 | 4.37 | ± | 0.531 | |||
| Average | 4.90 | ± | 0.548 | ||||
| Test Chemical | Chloroform |
200 |
2354 | 25 | 6.11 | ± | 0.402 |
| 2363 | 25 | 5.30 | ± | 0.562 | |||
| 2375 | 25 | 7.63 | ± | 0.541 | |||
| 2391 | 25 | 6.56 | ± | 0.462 | |||
| Average | 6.40 | ± | 0.486 | ||||
| Test Chemical | Chloroform |
400 |
2345 | 25 | 6.05 | ± | 0.414 |
| 2346 | 25 | 7.93 | ± | 0.830 | |||
| 2364 | 25 | 7.62 | ± | 0.555 | |||
| 2372 | 25 | 9.31 | ± | 0.715 | |||
| Average | 7.74 | ± | 0.670 | ||||
| Test Chemical | Chloroform |
800 |
2355 | 25 | 7.70 | ± | 0.655 |
| 2357 | 25 | 7.59 | ± | 0.572 | |||
| 2383 | 25 | 8.08 | ± | 0.766 | |||
| 2385 | 25 | 5.63 | ± | 0.534 | |||
| Average | 7.26 | ± | 0.549 | ||||
| Positive Control | Dimethylbenzanthracene |
200 |
2359 | 25 | 12.76 | ± | 0.970 |
| 2362 | 25 | 14.35 | ± | 1.148 | |||
| 2378 | 25 | 12.19 | ± | 1.015 | |||
| 2389 | 25 | 12.76 | ± | 0.951 | |||
| Average | 13.03 | ± | 0.464 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed