| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01867-0012-0000-7 |
| Chemical Name: | Chloroform |
| CASRN: | 67-66-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 142011_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/25/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6054 | 25 | 6.58 | ± | 0.522 |
| 6059 | 25 | 5.73 | ± | 0.481 | |||
| 6070 | 25 | 4.60 | ± | 0.428 | |||
| 6071 | 25 | 6.49 | ± | 0.466 | |||
| Average | 5.86 | ± | 0.457 | ||||
| Test Chemical | Chloroform |
100 |
6051 | 25 | 5.68 | ± | 0.491 |
| 6052 | 25 | 5.77 | ± | 0.418 | |||
| 6056 | 25 | 8.20 | ± | 0.758 | |||
| 6062 | 25 | 6.11 | ± | 0.408 | |||
| Average | 6.43 | ± | 0.593 | ||||
| Test Chemical | Chloroform |
200 |
6050 | 25 | 5.42 | ± | 0.378 |
| 6072 | 25 | 5.39 | ± | 0.482 | |||
| 6073 | 25 | 6.04 | ± | 0.427 | |||
| 6078 | 25 | 4.15 | ± | 0.385 | |||
| Average | 5.25 | ± | 0.398 | ||||
| Test Chemical | Chloroform |
400 |
6058 | 25 | 4.42 | ± | 0.357 |
| 6061 | 25 | 5.89 | ± | 0.486 | |||
| 6065 | 25 | 6.53 | ± | 0.490 | |||
| 6077 | 25 | 4.74 | ± | 0.505 | |||
| Average | 5.40 | ± | 0.493 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6049 | 25 | 13.76 | ± | 1.039 |
| 6055 | 25 | 13.06 | ± | 0.703 | |||
| 6063 | 25 | 13.74 | ± | 0.900 | |||
| 6079 | 25 | 12.15 | ± | 0.843 | |||
| Average | 13.18 | ± | 0.379 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed