| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01766-0011-0000-4 |
| Chemical Name: | C.I. Acid red 14 |
| CASRN: | 3567-69-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 142045_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/09/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7069 | 25 | 7.19 | ± | 0.546 |
| 7073 | 25 | 7.19 | ± | 0.737 | |||
| 7082 | 25 | 6.77 | ± | 0.387 | |||
| 7111 | 25 | 7.43 | ± | 0.618 | |||
| Average | 7.14 | ± | 0.138 | ||||
| Test Chemical | C.I. Acid red 14 |
450 |
7095 | 25 | 4.97 | ± | 0.544 |
| 7097 | 25 | 8.86 | ± | 0.740 | |||
| 7100 | 25 | 6.89 | ± | 0.636 | |||
| 7103 | 25 | 5.40 | ± | 0.503 | |||
| Average | 6.53 | ± | 0.880 | ||||
| Test Chemical | C.I. Acid red 14 |
900 |
7096 | 25 | 8.88 | ± | 0.948 |
| 7099 | 25 | 6.38 | ± | 0.677 | |||
| 7101 | 25 | 10.08 | ± | 1.161 | |||
| 7109 | 25 | 8.24 | ± | 0.619 | |||
| Average | 8.41 | ± | 0.774 | ||||
| Test Chemical | C.I. Acid red 14 |
1800 |
7104 | 25 | 7.98 | ± | 0.666 |
| 7105 | 25 | 6.80 | ± | 0.693 | |||
| 7107 | 25 | 15.04 | ± | 0.978 | |||
| 7110 | 25 | 15.41 | ± | 1.290 | |||
| Average | 11.31 | ± | 2.275 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7056 | 25 | 14.76 | ± | 0.995 |
| 7067 | 25 | 12.38 | ± | 0.976 | |||
| 7092 | 25 | 14.40 | ± | 0.815 | |||
| 7102 | 25 | 14.30 | ± | 0.897 | |||
| Average | 13.97 | ± | 0.535 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed