| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01766-0011-0000-4 |
| Chemical Name: | C.I. Acid red 14 |
| CASRN: | 3567-69-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 142045_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/27/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7446 | 25 | 4.67 | ± | 0.378 |
| 7464 | 25 | 4.82 | ± | 0.482 | |||
| 7496 | 25 | 5.34 | ± | 0.508 | |||
| 7500 | 25 | 4.67 | ± | 0.417 | |||
| Average | 4.87 | ± | 0.160 | ||||
| Test Chemical | C.I. Acid red 14 |
450 |
7447 | 25 | 6.72 | ± | 0.526 |
| 7452 | 25 | 10.47 | ± | 1.316 | |||
| 7453 | 25 | 7.53 | ± | 0.712 | |||
| 7460 | 25 | 6.39 | ± | 0.724 | |||
| Average | 7.78 | ± | 0.930 | ||||
| Test Chemical | C.I. Acid red 14 |
900 |
7450 | 25 | 6.41 | ± | 0.539 |
| 7451 | 25 | 7.89 | ± | 1.119 | |||
| 7455 | 25 | 7.38 | ± | 0.827 | |||
| 7463 | 26 | 5.12 | ± | 0.414 | |||
| Average | 6.69 | ± | 0.610 | ||||
| Test Chemical | C.I. Acid red 14 |
1800 |
7444 | 25 | 7.18 | ± | 0.531 |
| 7449 | 25 | 10.31 | ± | 1.557 | |||
| 7458 | 25 | 12.20 | ± | 0.970 | |||
| 7461 | 25 | 8.20 | ± | 1.223 | |||
| Average | 9.45 | ± | 1.119 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7448 | 25 | 9.43 | ± | 0.812 |
| 7473 | 25 | 11.04 | ± | 0.615 | |||
| 7485 | 25 | 8.25 | ± | 0.580 | |||
| 7511 | 25 | 7.42 | ± | 0.663 | |||
| Average | 9.03 | ± | 0.784 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed