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Study Information
Study Attribute Value
CEBS Accession Number: 002-01314-0015-0000-7
Chemical Name: 2-Chloromethylpyridine hydrochloride
CASRN: 6959-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 145263_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/10/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
 0.5       
 2334 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2335 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2337 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    2338 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2339 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    2340 50 1 0 0 0 0 0 0 1 0.02 0.02 6.00 6.00
    2341 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.8 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 4.50 3.00
± SEM                         0.01 0.00 0.91 0.53
 
Test Chemical 2-Chloromethylpyridine hydrochloride 
75         
 2302 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2303 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2304 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2305 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2306 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2307 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2308 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2309 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.01 0.75 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Test Chemical 2-Chloromethylpyridine hydrochloride 
150         
 2310 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2311 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2312 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    2313 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2314 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2315 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2316 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2317 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.63 0.37
 
Test Chemical 2-Chloromethylpyridine hydrochloride 
300         
 2318 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2319 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2320 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2321 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2322 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2323 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2324 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2325 50 3 0 0 0 0 0 1 4 0.08 0.08 8.00 8.00
Average         0.6 0.3 0.0 0.0 0.0 0.0 0.1 1.0 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 1.00 1.05
 
Vehicle Control No Stressor 
 0         
 2326 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    2327 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2328 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    2329 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2330 50 3 0 0 0 0 0 0 3 0.06 0.06 2.00 2.00
    2331 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2332 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2333 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 0.4 0.0 0.1 0.0 0.0 0.1 1.1 0.02 0.01 1.50 0.50
± SEM                         0.01 0.01 0.33 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation