| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01314-0014-0000-6 |
| Chemical Name: | 2-Chloromethylpyridine hydrochloride |
| CASRN: | 6959-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 145263_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/19/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
2206 | 25 | 7.49 | ± | 0.600 |
| 2207 | 25 | 6.94 | ± | 1.225 | |||
| 2209 | 25 | 5.97 | ± | 0.817 | |||
| 2210 | 25 | 5.17 | ± | 0.649 | |||
| Average | 6.40 | ± | 0.515 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
75 |
2191 | 25 | 6.10 | ± | 1.006 |
| 2192 | 25 | 4.50 | ± | 0.562 | |||
| 2193 | 25 | 4.01 | ± | 0.425 | |||
| 2195 | 25 | 5.86 | ± | 1.104 | |||
| Average | 5.12 | ± | 0.509 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
150 |
2197 | 25 | 3.29 | ± | 0.389 |
| 2198 | 25 | 3.49 | ± | 0.442 | |||
| 2199 | 25 | 2.78 | ± | 0.336 | |||
| 2200 | 25 | 4.87 | ± | 0.861 | |||
| Average | 3.60 | ± | 0.445 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
300 |
2201 | 25 | 7.42 | ± | 0.817 |
| 2202 | 25 | 8.41 | ± | 0.851 | |||
| 2203 | 25 | 7.35 | ± | 0.708 | |||
| 2204 | 25 | 10.35 | ± | 0.753 | |||
| Average | 8.39 | ± | 0.698 | ||||
| Positive Control | Mitomycin-C |
6.9 |
2211 | 25 | 49.35 | ± | 2.715 |
| 2212 | 25 | 45.83 | ± | 2.489 | |||
| 2213 | 25 | 42.60 | ± | 2.405 | |||
| 2215 | 25 | 34.86 | ± | 1.714 | |||
| Average | 43.12 | ± | 3.091 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed