| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01314-0014-0000-6 |
| Chemical Name: | 2-Chloromethylpyridine hydrochloride |
| CASRN: | 6959-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 145263_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/10/1985 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | IP/IJ x 1, 17 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
2326 | 25 | 3.41 | ± | 0.342 |
| 2327 | 25 | 3.67 | ± | 0.462 | |||
| 2328 | 25 | 4.11 | ± | 0.304 | |||
| 2329 | 25 | 3.24 | ± | 0.413 | |||
| Average | 3.61 | ± | 0.189 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
75 |
2302 | 25 | 4.20 | ± | 0.440 |
| 2303 | 25 | 5.78 | ± | 0.676 | |||
| 2304 | 25 | 3.56 | ± | 0.435 | |||
| 2305 | 25 | 4.08 | ± | 0.574 | |||
| Average | 4.42 | ± | 0.479 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
150 |
2310 | 25 | 3.63 | ± | 0.445 |
| 2311 | 25 | 5.29 | ± | 0.509 | |||
| 2312 | 25 | 4.56 | ± | 0.513 | |||
| 2313 | 25 | 4.37 | ± | 0.573 | |||
| Average | 4.46 | ± | 0.341 | ||||
| Test Chemical | 2-Chloromethylpyridine hydrochloride |
300 |
2318 | 25 | 3.63 | ± | 0.382 |
| 2319 | 25 | 5.53 | ± | 0.720 | |||
| 2320 | 25 | 4.74 | ± | 0.503 | |||
| 2321 | 25 | 4.57 | ± | 0.500 | |||
| Average | 4.62 | ± | 0.391 | ||||
| Positive Control | Mitomycin-C |
1 |
2334 | 25 | 11.41 | ± | 1.191 |
| 2335 | 25 | 11.28 | ± | 0.715 | |||
| 2336 | 25 | 11.49 | ± | 0.789 | |||
| 2337 | 25 | 10.82 | ± | 1.046 | |||
| Average | 11.24 | ± | 0.150 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed