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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0021-0000-3
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 150910_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/24/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4686 50 4 8 0 0 0 0 0 12 0.24 0.08 14.00 8.00
    4687 50 16 10 0 0 0 0 1 27 0.54 0.34 54.00 34.00
    4688 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4689 50 7 3 2 0 0 0 0 12 0.24 0.18 24.00 18.00
    4690 50 7 1 0 0 0 0 0 8 0.16 0.14 16.00 14.00
    4691 50 10 7 1 2 0 0 0 20 0.40 0.22 40.00 22.00
    4692 50 1 5 0 0 0 0 0 6 0.12 0.02 12.00 2.00
    4693 50 15 5 4 1 0 0 0 25 0.50 0.38 50.00 38.00
Average         7.5 5.1 0.9 0.4 0.0 0.0 0.1 14.0 0.28 0.17 26.75 17.00
± SEM                         0.06 0.05 6.65 4.93
 
Test Chemical Furfuryl alcohol 
75         
 4616 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4617 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4618 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4619 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    4620 50 1 0 1 0 0 0 0 2 0.04 0.04 2.00 4.00
    4621 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4622 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4623 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 0.6 0.3 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.00 2.00
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Furfuryl alcohol 
150         
 4626 50 8 1 0 0 0 0 0 9 0.18 0.16 18.00 16.00
    4627 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 6.00
    4628 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4629 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4630 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4631 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4632 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4633 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.1 0.5 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.04 5.00 4.00
± SEM                         0.02 0.02 2.20 1.93
 
Test Chemical Furfuryl alcohol 
300         
 4636 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4637 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4638 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4639 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4640 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4641 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4642 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4643 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.00 0.75 0.00
± SEM                         0.01 0.00 0.53 0.00
 
Vehicle Control No Stressor 
 0         
 4676 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4677 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4678 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4679 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4680 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4681 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4682 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4683 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         1.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 2.00
± SEM                         0.01 0.01 1.03 1.00
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation