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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0021-0000-3
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 150910_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/12/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7774 50 51 1 1 0 1 0 0 54 1.08 1.06 34.00 34.00
    7775 50 60 13 3 0 0 0 4 80 1.60 1.34 48.00 42.00
    7776 50 7 3 2 1 1 0 0 14 0.28 0.20 16.00 12.00
    7777 50 20 11 1 0 0 0 0 32 0.64 0.42 38.00 28.00
    7778 50 27 10 2 0 0 0 0 39 0.78 0.58 32.00 22.00
    7779 50 17 3 2 0 1 0 0 23 0.46 0.40 26.00 24.00
    7780 50 31 3 1 0 2 0 3 40 0.80 0.74 34.00 34.00
    7781 50 27 9 2 0 1 0 1 40 0.80 0.62 30.00 24.00
Average         30.0 6.6 1.8 0.1 0.8 0.0 1.0 40.3 0.81 0.67 32.25 27.50
± SEM                         0.14 0.13 3.26 3.25
 
Test Chemical Furfuryl alcohol 
50         
 7734 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7735 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7736 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    7737 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7738 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7739 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7740 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7741 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.5 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 2.75 2.00
± SEM                         0.01 0.01 0.92 0.76
 
Test Chemical Furfuryl alcohol 
100         
 7744 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7745 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7746 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    7747 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7748 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7749 50 6 1 0 0 0 0 0 7 0.14 0.12 12.00 10.00
    7750 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    7751 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
Average         2.1 0.6 0.0 0.1 0.0 0.0 0.0 2.9 0.06 0.04 5.25 4.00
± SEM                         0.01 0.01 1.19 1.07
 
Test Chemical Furfuryl alcohol 
200         
 7754 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7755 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7756 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    7757 50 3 0 1 1 0 0 0 5 0.10 0.08 8.00 6.00
    7758 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7759 50 6 0 0 0 0 0 0 6 0.12 0.12 12.00 12.00
    7760 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7761 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         2.4 0.4 0.1 0.1 0.0 0.0 0.0 3.0 0.06 0.05 5.50 4.50
± SEM                         0.02 0.02 1.55 1.40
 
Vehicle Control No Stressor 
 0         
 7764 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7765 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7766 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7767 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7768 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    7769 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7770 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.9 0.6 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.02 2.57 1.43
± SEM                         0.01 0.01 0.84 0.57
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation