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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0021-0000-3
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 150910_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/09/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9398 50 23 7 0 0 0 0 0 30 0.60 0.46 16.00 10.00
    9399 50 36 23 0 0 0 0 0 59 1.18 0.72 54.00 48.00
    9400 50 7 15 0 1 0 0 0 23 0.46 0.14 28.00 10.00
    9402 50 74 12 4 0 1 0 0 91 1.82 1.58 38.00 30.00
    9403 50 50 13 2 1 0 0 0 66 1.32 1.04 42.00 32.00
    9404 50 13 10 0 0 0 0 0 23 0.46 0.26 24.00 18.00
    9405 50 30 9 1 0 0 0 0 40 0.80 0.62 34.00 26.00
Average         33.3 12.7 1.0 0.3 0.1 0.0 0.0 47.4 0.95 0.69 33.71 24.86
± SEM                         0.19 0.19 4.73 5.12
 
Test Chemical Furfuryl alcohol 
50         
 9358 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9359 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9360 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    9361 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9362 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9363 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9364 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9365 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.00 1.50
± SEM                         0.01 0.01 0.76 0.50
 
Test Chemical Furfuryl alcohol 
100         
 9368 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9369 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9370 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9371 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9372 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    9373 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9374 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9375 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 0.3 0.1 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 1.75
± SEM                         0.01 0.01 0.70 0.70
 
Test Chemical Furfuryl alcohol 
200         
 9378 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9379 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    9380 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9381 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9382 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9383 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    9384 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    9385 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.9 1.0 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.75 2.00
± SEM                         0.01 0.01 1.39 1.00
 
Vehicle Control No Stressor 
 0         
 9388 50 10 1 0 0 0 0 0 11 0.22 0.20 4.00 2.00
    9389 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9390 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    9391 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9392 50 2 6 0 0 0 0 0 8 0.16 0.04 16.00 4.00
    9393 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9394 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9395 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
Average         1.9 1.6 0.0 0.0 0.0 0.0 0.0 3.5 0.07 0.04 4.25 1.50
± SEM                         0.03 0.02 1.91 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation