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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0021-0000-3
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 150910_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/02/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11010 50 28 8 2 0 0 0 0 38 0.76 0.60 34.00 22.00
    11011 50 9 14 0 1 0 0 0 24 0.48 0.18 34.00 16.00
    11012 50 11 10 4 0 0 0 0 25 0.50 0.30 22.00 18.00
    11013 50 24 10 0 0 0 0 0 34 0.68 0.48 26.00 20.00
    11014 50 21 10 0 0 0 0 1 32 0.64 0.44 32.00 26.00
    11015 50 18 4 0 0 0 0 0 22 0.44 0.36 20.00 16.00
    11016 50 7 8 2 0 0 0 0 17 0.34 0.18 20.00 14.00
    11017 50 6 4 0 0 0 0 0 10 0.20 0.12 14.00 12.00
Average         15.5 8.5 1.0 0.1 0.0 0.0 0.1 25.3 0.51 0.33 25.25 18.00
± SEM                         0.07 0.06 2.64 1.60
 
Test Chemical Furfuryl alcohol 
50         
 10970 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10971 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10973 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10974 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10975 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10976 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10977 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10978 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.25
± SEM                         0.01 0.01 0.80 0.53
 
Test Chemical Furfuryl alcohol 
100         
 10980 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10981 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10982 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10984 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10986 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10987 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10988 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10989 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.75
± SEM                         0.00 0.00 0.38 0.37
 
Test Chemical Furfuryl alcohol 
200         
 10990 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 8.00
    10991 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10992 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10993 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10994 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10995 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10996 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    10997 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.9 0.0 0.0 0.0 0.0 0.1 1.8 0.04 0.02 3.00 1.50
± SEM                         0.02 0.01 1.25 0.98
 
Vehicle Control No Stressor 
 0         
 11000 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11001 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11002 50 2 5 0 0 0 0 0 7 0.14 0.04 6.00 4.00
    11003 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11004 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11005 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11006 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11007 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.1 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.00 1.75
± SEM                         0.02 0.01 0.93 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation