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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0022-0000-4
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 163229_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/01/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(ug/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7221 50 5 5 0 0 0 0 0 10 0.20 0.10 12.00 10.00
    7222 50 10 6 2 0 0 0 0 18 0.36 0.24 22.00 14.00
    7223 50 8 9 0 0 0 0 0 17 0.34 0.16 16.00 10.00
    7224 50 9 10 0 0 0 0 0 19 0.38 0.18 20.00 12.00
    7225 50 10 4 0 0 0 0 0 14 0.28 0.20 18.00 16.00
    7227 50 10 8 0 1 0 0 0 19 0.38 0.20 22.00 16.00
    7228 50 8 8 0 0 0 0 0 16 0.32 0.16 16.00 12.00
    7229 50 7 10 0 0 0 0 0 17 0.34 0.14 24.00 14.00
Average         8.4 7.5 0.3 0.1 0.0 0.0 0.0 16.3 0.33 0.17 18.75 13.00
± SEM                         0.02 0.02 1.41 0.85
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 7141 50 4 13 0 0 0 0 0 17 0.34 0.08 18.00 8.00
    7142 50 3 2 0 0 0 0 0 5 0.10 0.06 6.00 4.00
    7143 50 5 4 1 0 0 0 0 10 0.20 0.12 14.00 12.00
    7144 50 4 14 0 0 0 0 0 18 0.36 0.08 16.00 8.00
    7145 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7146 50 7 4 0 0 0 0 0 11 0.22 0.14 14.00 12.00
    7147 50 7 5 0 0 0 0 0 12 0.24 0.14 16.00 12.00
    7148 50 2 4 1 0 0 0 1 8 0.16 0.08 12.00 6.00
Average         4.4 5.8 0.3 0.0 0.0 0.0 0.1 10.5 0.21 0.10 12.75 8.50
± SEM                         0.04 0.01 1.60 1.12
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
500         
 7151 50 10 7 0 0 0 0 0 17 0.34 0.20 20.00 14.00
    7152 50 8 4 1 0 0 0 0 13 0.26 0.18 18.00 16.00
    7153 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    7154 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    7157 50 4 3 0 0 0 0 0 7 0.14 0.08 8.00 6.00
    7158 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    7159 50 5 7 0 0 0 0 0 12 0.24 0.10 16.00 10.00
Average         5.6 3.4 0.1 0.0 0.0 0.0 0.0 9.1 0.18 0.11 13.14 10.00
± SEM                         0.04 0.02 1.79 1.57
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
1000         
 7161 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    7162 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    7163 50 7 0 0 0 0 0 0 7 0.14 0.14 14.00 14.00
    7164 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    7165 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    7166 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7167 50 6 1 0 0 0 0 0 7 0.14 0.12 14.00 12.00
    7168 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 8.00
Average         4.0 0.9 0.0 0.0 0.0 0.0 0.0 4.9 0.10 0.08 9.00 7.75
± SEM                         0.01 0.01 1.46 1.44
 
Vehicle Control No Stressor 
 0         
 7206 50 2 9 0 0 0 0 0 11 0.22 0.04 14.00 4.00
    7207 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    7208 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7209 50 7 4 0 0 0 0 0 11 0.22 0.14 10.00 6.00
    7210 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7211 50 5 0 0 0 0 0 0 5 0.10 0.10 4.00 4.00
    7212 50 1 2 1 0 0 0 0 4 0.08 0.04 8.00 4.00
    7213 50 5 11 0 0 0 0 0 16 0.32 0.10 20.00 8.00
Average         3.3 3.6 0.1 0.0 0.0 0.0 0.0 7.0 0.14 0.07 9.00 4.75
± SEM                         0.04 0.02 2.17 0.84
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation