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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0022-0000-4
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 163229_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/20/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(ug/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12165 50 15 5 0 0 0 0 0 20 0.40 0.30 30.00 26.00
    12166 50 106 7 0 1 0 0 0 114 2.28 2.12 40.00 30.00
    12167 50 123 9 1 0 0 0 0 133 2.66 2.48 42.00 30.00
    12168 50 9 14 0 0 0 0 0 23 0.46 0.18 32.00 18.00
    12169 50 22 13 0 1 0 0 1 37 0.74 0.46 40.00 22.00
    12170 50 27 28 1 1 0 0 0 57 1.14 0.56 44.00 32.00
    12171 50 75 6 1 0 0 0 0 82 1.64 1.52 36.00 30.00
    12172 50 54 22 1 0 0 0 0 77 1.54 1.10 54.00 38.00
Average         53.9 13.0 0.5 0.4 0.0 0.0 0.1 67.9 1.36 1.09 39.75 28.25
± SEM                         0.29 0.31 2.66 2.19
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 12095 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12096 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    12097 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12098 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12099 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12100 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12101 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12102 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.9 0.3 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 1.75
± SEM                         0.01 0.01 0.88 0.70
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
500         
 12105 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12106 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12107 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12108 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12110 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12111 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12112 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
1000         
 12115 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    12116 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12117 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12118 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12119 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12120 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12121 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12122 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.75 1.25
± SEM                         0.01 0.00 0.45 0.37
 
Vehicle Control No Stressor 
 0         
 12156 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12157 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12158 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12159 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12160 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12161 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12162 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12163 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.25 2.25
± SEM                         0.01 0.01 0.92 0.88
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation