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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0022-0000-4
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 163229_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/11/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(ug/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12660 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    12661 50 7 1 0 0 0 0 0 8 0.16 0.14 16.00 14.00
    12662 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    12663 50 5 3 1 2 0 0 0 11 0.22 0.12 20.00 14.00
    12664 50 4 5 0 0 0 0 2 11 0.22 0.12 18.00 10.00
    12665 50 3 2 2 0 0 0 1 8 0.16 0.12 14.00 10.00
    12666 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12667 50 0 2 1 1 0 0 0 4 0.08 0.02 6.00 2.00
Average         3.5 2.3 0.5 0.4 0.0 0.0 0.4 7.0 0.14 0.09 12.50 8.25
± SEM                         0.02 0.02 2.03 1.67
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 12620 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12621 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12622 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12623 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12624 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    12625 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12626 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12627 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.4 0.5 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 0.50 0.65
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
500         
 12333 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12630 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12631 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    12632 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12634 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12635 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12636 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12637 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.3 0.6 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.03 3.75 2.50
± SEM                         0.01 0.01 1.10 0.73
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
1000         
 12640 50 2 2 1 0 0 0 0 5 0.10 0.06 8.00 6.00
    12641 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12642 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12643 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12644 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12645 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12646 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12647 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.6 0.1 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.25 2.25
± SEM                         0.01 0.01 1.00 0.70
 
Vehicle Control No Stressor 
 0         
 12650 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12651 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12653 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12655 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12656 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    12657 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12658 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12659 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.6 0.9 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 3.00 1.25
± SEM                         0.01 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation